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Case Reports
. 2022 Oct 20;7(10):319.
doi: 10.3390/tropicalmed7100319.

Visceral Leishmaniasis after Anti-Interleukin 17A (IL-17A) Therapy in a Patient Affected by Psoriatic Arthritis

Tommaso Lupia  1 , Silvia Corcione  2   3 , Valentina Fornari  2 , Barbara Rizzello  2 , Roberta Bosio  2 , Maria Teresa Brusa  1 , Francesco Giuseppe De Rosa  1   2
Affiliations
Case Reports

Visceral Leishmaniasis after Anti-Interleukin 17A (IL-17A) Therapy in a Patient Affected by Psoriatic Arthritis

Tommaso Lupia et al. Trop Med Infect Dis. .

Abstract

The reactivation of latent Leishmania infection in chronic diseases and immunocompromised hosts is a broad and heterogeneous field in medicine and infectious diseases. We reported one of the first cases of Visceral Leishmaniasis occurring in a Caucasian middle-aged man living in an endemic country (Italy) for Leishmania infantum infection following secukinumab treatment for psoriatic arthritis. The patient was cured with a Liposomal Amphotericin B (L-AmB, 3 mg/Kg on days 1-5, followed by a dose on days 10, 17, 24, 31 and 38) regimen, after which his anti-interleukin 17 treatment was restarted-without recurrence in the follow-up.

Keywords: Leishmania; arthritis; interleukin-17; psoriasis; secukinumab.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Timeline of treatment of psoriasis until diagnostic of visceral leishmaniasis. Abbreviations: MTX: metothrexate.
Figure 2
Figure 2
Hematoxylin-eosine stain on osteomedullary biopsy showing amastigotes (black arrows). Caption: Hematoxylin-eosin shows histiocytes containing innumerable hematoxylinophilic corpuscles compatible with Leishmania amastigotes (arrows), also present in the interstitium (20×).
See this image and copyright information in PMC

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