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Case Reports
. 2022 Nov 26;62(11):850-855.
doi: 10.5692/clinicalneurol.cn-001764. Epub 2022 Oct 26.

[A case of neuroleptic malignant syndrome caused by discontinuation of psychotropic drugs]

[Article in Japanese]
Yoshiya Takahashi  1 , Masamitsu Yaguchi  2 , Hisa Yaguchi  2 , Atsuhito Togashi  1 , Mitsunori Suzuki  3
Affiliations
Case Reports

[A case of neuroleptic malignant syndrome caused by discontinuation of psychotropic drugs]

[Article in Japanese]
Yoshiya Takahashi et al. Rinsho Shinkeigaku. .

Abstract

A 71-year-old woman with schizophrenia and diabetes discontinued psychotropic drugs due to right purulent knee bursitis. Five days after discontinuation, she presented with a fever of >40°C, severe disturbance of consciousness, lead-pipe muscle rigidity, tachypnea, and hypertension. She was diagnosed with neuroleptic malignant syndrome (NMS) induced by the discontinuation of psychotropic drugs. The patient's symptoms improved after dantrolene administration and systemic management. We investigated the clinical characteristics of cases with NMS induced by the discontinuation of psychotropic drugs reported in Japan, including the present case. When psychotropic drugs are discontinued, patients should be monitored for signs of NMS. Strict management of early onset NMS is needed to prevent the condition from worsening.

Keywords: cholinergic rebound; discontinuation of psychotropic drugs; neuroleptic malignant syndrome.

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