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Review
. 2022 Sep 25;10(10):2392.
doi: 10.3390/biomedicines10102392.

Mineral-Enriched Postbiotics: A New Perspective for Microbial Therapy to Prevent and Treat Gut Dysbiosis

Laura-Dorina Dinu  1 , Ionela Avram  2 , Diana-Roxana Pelinescu  2 , Emanuel Vamanu  1
Affiliations
Review

Mineral-Enriched Postbiotics: A New Perspective for Microbial Therapy to Prevent and Treat Gut Dysbiosis

Laura-Dorina Dinu et al. Biomedicines. .

Abstract

Postbiotics are non-viable probiotic preparations that confer a health benefit on the host. In the last years, scientific literature has proved that postbiotics have health-promoting features and technological advantages compared to probiotics, augmenting their full potential application in the food and pharmaceutical industries. The current work comprehensively summarizes the benefits and potential applications of postbiotics and essential mineral-enriched biomass and proposes a new strategy for microbial therapy-mineral-enriched postbiotics. We hypothesize and critically review the relationship between micronutrients (calcium, magnesium, iron, zinc, selenium) and postbiotics with gut microbiota, which has been barely explored yet, and how the new approach could be involved in the gut microbiome modulation to prevent and treat gut dysbiosis. Additionally, the bioactive molecules and minerals from postbiotics could influence the host mineral status, directly or through gut microbiota, which increases the mineral bioavailability. The review increases our understanding of the health improvements of mineral-enriched postbiotics, including antioxidant functions, highlighting their perspective on microbial therapy to prevent and threaten gut-related diseases.

Keywords: gut dysbiosis; microbial therapy; microbiota modulation; mineral bioavailability; mineral-enriched postbiotics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Molecules produced by mineral-enriched postbiotics.
Figure 2
Figure 2
Mineral-enriched postbiotic advantages and beneficial health effects.
See this image and copyright information in PMC

References

    1. Kaur S., Thukral S.K., Kaur P., Samota M.K. Perturbations Associated with Hungry Gut Microbiome and Postbiotic Perspectives to Strengthen the Microbiome Health. Future Foods. 2021;4:100043. doi: 10.1016/j.fufo.2021.100043. - DOI
    1. Żółkiewicz J., Marzec A., Ruszczyński M., Feleszko W. Postbiotics—A Step beyond Pre- and Probiotics. Nutrients. 2020;23:2189. doi: 10.3390/nu12082189. - DOI - PMC - PubMed
    1. Siciliano R.A., Reale A., Mazzeo M.F., Morandi S., Silvetti T., Brasca M. Paraprobiotics: A new perspective for functional foods and nutraceuticals. Nutrients. 2021;13:1225. doi: 10.3390/nu13041225. - DOI - PMC - PubMed
    1. Hill C., Guarner F., Reid G., Gibson G.R., Merenstein D.J., Pot B., Morelli L., Canani R.B., Flint H.J., Salminen S., et al. Expert consensus document: The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat. Rev. Gastroenterol. Hepatol. 2014;11:506–514. doi: 10.1038/nrgastro.2014.66. - DOI - PubMed
    1. [(accessed on 23 August 2022)]. Available online: www.marketsandmarkets.com.

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