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Review
. 2022 Oct 9;10(10):2523.
doi: 10.3390/biomedicines10102523.

Acne Vulgaris, Atopic Dermatitis and Rosacea: The Role of the Skin Microbiota-A Review

Giorgia Condrò  1 , Marta Guerini  1 , Michela Castello  2   3 , Paola Perugini  1   4
Affiliations
Review

Acne Vulgaris, Atopic Dermatitis and Rosacea: The Role of the Skin Microbiota-A Review

Giorgia Condrò et al. Biomedicines. .

Abstract

The skin harbors a huge number of different microorganisms such as bacteria, fungi and viruses, and it acts as a protective shield to prevent the invasion of pathogens and to maintain the health of the commensal microbiota. Several studies, in fact, have shown the importance of the skin microbiota for healthy skin. However, this balance can be altered by intrinsic and extrinsic factors, leading to the development of skin disease, such as acne vulgaris (AV), atopic dermatitis (AD) and rosacea(RS). Although these diseases are widespread and affect both adolescents and adults, the scientific correlation between these disorders and the skin microbiota and physiological parameters (TEWL, hydration and lipid composition) is still unclear. This review aims to investigate the current literature regarding the correlation between the skin microbiota and its imbalance underlying microbiological aspects, how the skin microbiota changes over the course of the disease and the current possible treatments. The following reported studies show a general imbalance of the bacterial flora. For this reason, more in-depth studies are necessary to explore the different subspecies and strains involved in all three diseases.

Keywords: acne vulgaris; dermatitis; rosacea; skin bioengineering; skin disease.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Scheme of skin microbiota distribution on skin in a healthy condition. Image built on Power Point software.
Figure 2
Figure 2
Atopic dermatitis representation. This image describes the consequence of skin barrier damage. Image built on Power Point software.
Figure 3
Figure 3
Illustration of Cutibacterium acnes’ mechanism of action. Made with Power Point software.
See this image and copyright information in PMC

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