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Review
. 2022 Oct 13;10(10):2566.
doi: 10.3390/biomedicines10102566.

A Review on Therapeutic Potential of Natural Phytocompounds for Stroke

Farooq M Almutairi  1 , Aman Ullah  2 , Yusuf S Althobaiti  3   4 , Hafiz Muhammad Irfan  5 , Usman Shareef  6 , Halima Usman  6 , Sagheer Ahmed  6
Affiliations
Review

A Review on Therapeutic Potential of Natural Phytocompounds for Stroke

Farooq M Almutairi et al. Biomedicines. .

Abstract

Stroke is a serious condition that results from an occlusion of blood vessels that leads to brain damage. Globally, it is the second highest cause of death, and deaths from strokes are higher in older people than in the young. There is a higher rate of cases in urban areas compared to rural due to lifestyle, food, and pollution. There is no effective single medicine for the treatment of stroke due to the multiple causes of strokes. Thrombolytic agents, such as alteplase, are the main treatment for thrombolysis, while multiple types of surgeries, such ascraniotomy, thrombectomy, carotid endarterectomy, and hydrocephalus, can be performed for various forms of stroke. In this review, we discuss some promising phytocompounds, such as flavone C-glycoside (apigenin-8-C-β-D-glucopyranoside), eriodictyol, rosamirinic acid, 6″-O-succinylapigenin, and allicin, that show effectiveness against stroke. Future study paths are given, as well as suggestions for expanding the use of medicinal plants and their formulations for stroke prevention.

Keywords: ischemia; occlusion of blood; paralysis; phytocompounds; stroke.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Pictorial presentation of ischemic stroke, the consequence of reduced blood supply due to occlusion of the main cerebral artery, either temporarily or permanently. In this way, the central core becomes devoid of blood supply, and energy-dependent cell pumps malfunction, causing a build-up of Na+ and Ca+ and decreased energy production leading to the generation of Reactive Oxygen Species (ROS), and resulting in neuronal damage.
Figure 2
Figure 2
Promising phytocompound’s structures for stroke.
Figure 2
Figure 2
Promising phytocompound’s structures for stroke.
Figure 2
Figure 2
Promising phytocompound’s structures for stroke.
Figure 2
Figure 2
Promising phytocompound’s structures for stroke.
Figure 2
Figure 2
Promising phytocompound’s structures for stroke.
See this image and copyright information in PMC

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