Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct 20;10(10):2639.
doi: 10.3390/biomedicines10102639.

Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis

Anastasia V Poznyak  1 , Larisa Litvinova  2 , Paolo Poggio  3 , Alexander N Orekhov  1   4 , Alexandra A Melnichenko  4
Affiliations
Review

Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis

Anastasia V Poznyak et al. Biomedicines. .

Abstract

Lipid metabolism alterations are an important component of the pathogenesis of atherosclerosis. However, it is now clear that the atherogenesis process involves more than one mechanism, and more than one condition can predispose this condition. Multiple risk factors contribute to the atherosclerosis initiation and define its course. Familial hypercholesterolaemia is a disorder of lipid metabolism that often leads to atherosclerosis development. As is clear from the disease name, the hallmark is the increased levels of low-density lipoprotein cholesterol (LDL-C) in blood. This creates favourable conditions for atherogenesis. In this review, we briefly described the familial hypercholesterolaemia and summarized data on the relationship between familial hypercholesterolaemia and atherosclerosis.

Keywords: atherosclerosis; cholesterol; hypercholesterolaemia; lipid.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The potential relationship between FH and atherosclerosis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Viigimaa M., Heinsar S., Lovic D., Katsimardou A., Piperidou A., Duishvili D. New Horizons in the Pathogenesis, Pathophysiology and Treatment of Familial Hypercholesterolaemia. Curr. Pharm. Des. 2018;24:3599–3604. doi: 10.2174/1381612824666181009105305. - DOI - PubMed
    1. Moradi A., Maleki M., Ghaemmaghami Z., Khajali Z., Noohi F., Moghadam M.H., Kalyinia S., Mowla S.J., Seidah N.G., Malakootian M. Mutational Spectrum of LDLR and PCSK9 Genes Identified in Iranian Patients With Premature Coronary Artery Disease and Familial Hypercholesterolemia. Front Genet. 2021;12:625959. doi: 10.3389/fgene.2021.625959. - DOI - PMC - PubMed
    1. Vrablik M., Tichý L., Freiberger T., Blaha V., Satny M., Hubacek J.A. Genetics of Familial Hypercholesterolemia: New Insights. Front. Genet. 2020;11:574474. doi: 10.3389/fgene.2020.574474. - DOI - PMC - PubMed
    1. Bouhairie V.E., Goldberg A.C. Familial Hypercholesterolemia. Cardiol. Clin. 2015;33:169–179. doi: 10.1016/j.ccl.2015.01.001. - DOI - PMC - PubMed
    1. Weissglas-Volkov D., Pajukanta P. Genetic causes of high and low serum HDL-cholesterol. J. Lipid Res. 2010;51:2032–2057. doi: 10.1194/jlr.R004739. - DOI - PMC - PubMed