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Review
. 2022 Oct 20;10(10):2639.
doi: 10.3390/biomedicines10102639.

Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis

Anastasia V Poznyak  1 , Larisa Litvinova  2 , Paolo Poggio  3 , Alexander N Orekhov  1   4 , Alexandra A Melnichenko  4
Affiliations
Review

Familial Hypercholesterolaemia as a Predisposing Factor for Atherosclerosis

Anastasia V Poznyak et al. Biomedicines. .

Abstract

Lipid metabolism alterations are an important component of the pathogenesis of atherosclerosis. However, it is now clear that the atherogenesis process involves more than one mechanism, and more than one condition can predispose this condition. Multiple risk factors contribute to the atherosclerosis initiation and define its course. Familial hypercholesterolaemia is a disorder of lipid metabolism that often leads to atherosclerosis development. As is clear from the disease name, the hallmark is the increased levels of low-density lipoprotein cholesterol (LDL-C) in blood. This creates favourable conditions for atherogenesis. In this review, we briefly described the familial hypercholesterolaemia and summarized data on the relationship between familial hypercholesterolaemia and atherosclerosis.

Keywords: atherosclerosis; cholesterol; hypercholesterolaemia; lipid.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The potential relationship between FH and atherosclerosis.
See this image and copyright information in PMC

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