Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Sep 22;9(10):494.
doi: 10.3390/bioengineering9100494.

Review of Bioactivity, Isolation, and Identification of Active Compounds from Antrodia cinnamomea

Hua-Xiang Li  1 , Juan-Juan Wang  1 , Chun-Lei Lu  1 , Ya-Jun Gao  1 , Lu Gao  1 , Zhen-Quan Yang  1   2
Affiliations
Review

Review of Bioactivity, Isolation, and Identification of Active Compounds from Antrodia cinnamomea

Hua-Xiang Li et al. Bioengineering (Basel). .

Abstract

Antrodia cinnamomea is a precious and popular edible and medicinal mushroom. It has attracted increasing attention due to its various and excellent bioactivities, such as hepatoprotection, hypoglycemic, antioxidant, antitumor, anticancer, anti-inflammatory, immunomodulation, and gut microbiota regulation properties. To elucidate its bioactivities and develop novel functional foods or medicines, numerous studies have focused on the isolation and identification of the bioactive compounds of A. cinnamomea. In this review, the recent advances in bioactivity, isolation, purification, and identification methods of active compounds from A. cinnamomea were summarized. The present work is beneficial to the further isolation and discovery of new active compounds from A. cinnamomea.

Keywords: Antrodia cinnamomea; bioactive; compound; isolation; purification.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The chemical structures of the main bioactive components from Antrodia cinnamomea. (a) Triterpenoids, (b) ubiquinone derivatives, (c) maleic and succinic acid derivatives, (d) benzene derivatives.
Figure 1
Figure 1
The chemical structures of the main bioactive components from Antrodia cinnamomea. (a) Triterpenoids, (b) ubiquinone derivatives, (c) maleic and succinic acid derivatives, (d) benzene derivatives.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lu M.C., El-Shazly M., Wu T.Y., Du Y.C., Chang T.T., Chen C.F., Hsu Y.M., Lai K.H., Chiu C.P., Chang F.R., et al. Recent research and development of Antrodia cinnamomea. Pharmacol Ther. 2013;139:124–156. doi: 10.1016/j.pharmthera.2013.04.001. - DOI - PubMed
    1. Chang T.T., Chou W.N. Antrodia cinnamomea sp. nov. on Cinnamomum kanehirai in Taiwan. Mycol. Res. 1995;99:756–758. doi: 10.1016/S0953-7562(09)80541-8. - DOI
    1. Liu Y.K., Chen K.H., Leu Y.L., Way T.D., Wang L.W., Chen Y.J., Liu Y.M. Ethanol extracts of Cinnamomum kanehirai Hayata leaves induce apoptosis in human hepatoma cell through caspase-3 cascade. Onco Targets Ther. 2015;8:99–109. doi: 10.2147/OTT.S68765. - DOI - PMC - PubMed
    1. Jin Y., Liu H., Liu J., Xing H., Wang F., Deng L. Efficient production of 4-Acetylantroquinonol B from Antrodia cinnamomea through two-stage carbon source coordination optimization. Bioresour. Technol. Rep. 2021;15:100732. doi: 10.1016/j.biteb.2021.100732. - DOI
    1. Ao Z.H., Xu Z.H., Lu Z.M., Xu H.Y., Zhang X.M., Dou W.F. Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases. J. Ethnopharmacol. 2009;121:194–212. doi: 10.1016/j.jep.2008.10.039. - DOI - PubMed

LinkOut - more resources