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Editorial
. 2022 Sep 22;12(10):1276.
doi: 10.3390/brainsci12101276.

Fragile X Syndrome: Recent Research Updates toward Capturing Treatments' Improvement in Clinical Trials

Dejan B Budimirovic  1   2 , Dragana D Protic  3
Affiliations
Editorial

Fragile X Syndrome: Recent Research Updates toward Capturing Treatments' Improvement in Clinical Trials

Dejan B Budimirovic et al. Brain Sci. .

Abstract

This Brain Sciences 2020 Special Issue of nine manuscripts contribute novel data on treatment updates in fragile X syndrome (FXS) [...].

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Conflict of interest statement

Dejan B. Budimirovic has received funding from Zynerba Pharmaceuticals (ZYN2-CL-017, ZYN2-CL-033) as a principal investigator on clinical trials in FXS. He also consulted on clinical trial outcome measures in FXS (Seaside, Ovid). All the above funding has been directed to Kennedy Krieger Institute/the Johns Hopkins Medical Institutions; Dejan B. Budimirovic receives no personal funds and the Institute has no relevant financial interest in any of the commercial entities listed. Dragana Protic declare no conflict of interest.

References

    1. Budimirovic D.B., Berry-Kravis E., Erickson C.A., Hall S.S., Hessl D., Reiss A.L., King M.K., Abbeduto L., Kaufmann W.E. Updated report on tools to measure outcomes of clinical trials in fragile X syndrome. J. Neurodev. Disord. 2017;9:14. doi: 10.1186/s11689-017-9193-x. - DOI - PMC - PubMed
    1. Berry-Kravis E. Disease-Targeted Treatment Translation in Fragile X Syndrome as a Model for Neurodevelopmental Disorders. J. Child Neurol. 2022:8830738221089740. doi: 10.1177/08830738221089740. - DOI - PubMed
    1. Budimirovic D., Subramanian M. Neurobiology of Autism and Intellectual Disability: Fragile X Syndrome. In: Johnston M., Adams H., Fatemi A., editors. Neurobiology of Disease. Oxford University Press; New York, NY, USA: 2016. pp. 375–384.
    1. Protic D.D., Aishworiya R., Salcedo-Arellano M.J., Tang S.J., Milisavljevic J., Mitrovic F., Hagerman R.J., Budimirovic D.B. Fragile X Syndrome: From Molecular Aspect to Clinical Treatment. Int. J. Mol. Sci. 2022;23:1935. doi: 10.3390/ijms23041935. - DOI - PMC - PubMed
    1. Budimirovic B., Schlageter A., Filipovic-Sadic S., Protic D.D., Bram E., Mahone E.M., Nicholson K., Culp K., Javanmardi K., Kemppainen J., et al. A Genotype-Phenotype Study of High-Resolution FMR1 Nucleic Acid and Protein Analyses in Fragile X Patients with Neurobehavioral Assessments. Brain Sci. 2020;10:694. doi: 10.3390/brainsci10100694. - DOI - PMC - PubMed

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