Synthesis of Protein-Oligonucleotide Conjugates
- PMID: 36291732
- PMCID: PMC9599799
- DOI: 10.3390/biom12101523
Synthesis of Protein-Oligonucleotide Conjugates
Abstract
Nucleic acids and proteins form two of the key classes of functional biomolecules. Through the ability to access specific protein-oligonucleotide conjugates, a broader range of functional molecules becomes accessible which leverages both the programmability and recognition potential of nucleic acids and the structural, chemical and functional diversity of proteins. Herein, we summarize the available conjugation strategies to access such chimeric molecules and highlight some key case study examples within the field to showcase the power and utility of such technology.
Keywords: bioconjugation; oligonucleotides; proteins.
Conflict of interest statement
The authors declare no conflict of interest.
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References
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- Stephanopoulos N. Hybrid Nanostructures from the Self-Assembly of Proteins and DNA. Chem. 2020;6:364–405. doi: 10.1016/j.chempr.2020.01.012. - DOI
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