. 2022 Oct 5;12(10):2409.

doi: 10.3390/diagnostics12102409.

Clinical Value of Neutrophil CD64 Index, PCT, and CRP in Acute Pancreatitis Complicated with Abdominal Infection

Biao Wang¹, Rongzhu Tang², Shaohong Wu³, Ming Liu⁴, Fariha Kanwal⁵, Muhammad Fayyaz Ur Rehman⁶, Fang Wu⁷, Jianping Zhu³

Affiliations

¹ Department of Gastrointestinal Surgery, Renmin Hospital, Hubei University of Medicine, No. 39, Chaoyang Middle Road, Shiyan 442000, China.
² Department of Gastroenterology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, No. 358, Datong Road, Pudong New District, Shanghai 200137, China.
³ Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
⁴ Department of Emergency, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
⁵ Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
⁶ Institute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan.
⁷ Department of Gynecology, Obstetrics and Gynae Hospital, Fudan University, Shanghai 200437, China.

PMID: 36292098
PMCID: PMC9600359
DOI: 10.3390/diagnostics12102409

Clinical Value of Neutrophil CD64 Index, PCT, and CRP in Acute Pancreatitis Complicated with Abdominal Infection

Biao Wang et al. Diagnostics (Basel). 2022.

. 2022 Oct 5;12(10):2409.

doi: 10.3390/diagnostics12102409.

Authors

Biao Wang¹, Rongzhu Tang², Shaohong Wu³, Ming Liu⁴, Fariha Kanwal⁵, Muhammad Fayyaz Ur Rehman⁶, Fang Wu⁷, Jianping Zhu³

Affiliations

¹ Department of Gastrointestinal Surgery, Renmin Hospital, Hubei University of Medicine, No. 39, Chaoyang Middle Road, Shiyan 442000, China.
² Department of Gastroenterology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, No. 358, Datong Road, Pudong New District, Shanghai 200137, China.
³ Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
⁴ Department of Emergency, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
⁵ Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
⁶ Institute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan.
⁷ Department of Gynecology, Obstetrics and Gynae Hospital, Fudan University, Shanghai 200437, China.

PMID: 36292098
PMCID: PMC9600359
DOI: 10.3390/diagnostics12102409

Abstract

Objective: To study the clinical diagnostic value of neutrophil CD64 index, PCT, and CRP in patients with acute pancreatitis with abdominal infection. Methods: A number of patients with acute pancreatitis (n = 234) participated in the study. According to the infection and health conditions, they were further divided into the non-infection group (n = 122), infection group (n = 78), and sepsis group (n = 34), and 40 healthy subjects were selected in the control group (n = 40). Expression levels of infection indexes, such as CD64 index, PCT, and CRP, were detected and compared. ROC curves were drawn to compare the efficacy of each index in the diagnosis of acute pancreatitis with abdominal infection and sepsis. The study was retrospectively registered under the China Clinical Trial Registry as a trial number ChiCTR2100054308. Results: All indexes were significantly higher in three clinical groups than the healthy control group (p < 0.05). The CD64 index, CD64 positive rate, and PCT in the infected group were significantly higher than those in the uninfected group (ALL p < 0.05). The PCT of patients infected with Gram-negative bacteria was significantly higher than that of Gram-positive bacteria-infected patients (p < 0.05). CD64 index had the best diagnostic efficiency for acute pancreatitis infection, with 82.14% sensitivity, 88.51% specificity, and 0.707 Youden indexes. The CD64 Youden index (0.780) for sepsis diagnosis was the highest, while the AUC of PCT was the highest (0.897). Conclusion: CD64 index combined with PCT has good sensitivity and specificity in diagnosing acute pancreatitis infection and sepsis.

Keywords: CD64 index; abdominal infection; acute pancreatitis; neutrophil.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
ROC curve of infection indicators for the diagnosis of acute pancreatitis with abdominal infection.

**Figure 2**
ROC curves of infection indicators for the diagnosis of acute pancreatitis and sepsis.

See this image and copyright information in PMC

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Clinical Value of Neutrophil CD64 Index, PCT, and CRP in Acute Pancreatitis Complicated with Abdominal Infection

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Clinical Value of Neutrophil CD64 Index, PCT, and CRP in Acute Pancreatitis Complicated with Abdominal Infection

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