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. 1987 Sep 25;237(4822):1610-4.
doi: 10.1126/science.3629259.

Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system

C C Thompson, C Weinberger, R Lebo, R M Evans

Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system

C C Thompson et al. Science. .

Abstract

A complementary DNA clone derived from rat brain messenger RNA has been isolated on the basis of homology to the human thyroid hormone receptor gene. Expression of this complementary DNA produces a high-affinity binding protein for thyroid hormones. Sequence analysis and the mapping of this gene to a distinct human genetic locus indicate the existence of multiple human thyroid hormone receptors. Messenger RNA from this gene is expressed in a tissue-specific fashion with highest levels in the central nervous system.

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