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Case Reports
. 1987;16(5):360-3.
doi: 10.1007/BF00350961.

Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

J P Devogelaer, J Malghem, B Maldague, C Nagant de Deuxchaisnes
Case Reports

Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

J P Devogelaer et al. Skeletal Radiol. 1987.

Abstract

A 12-year-old female suffering from osteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration of therapy was 1 year. Radiological and clinical improvement was striking. Furthermore, X-rays of the bones showed large, parallel radio-opaque striae, corresponding exactly to the periods of therapy. These were present in all metaphyses.

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