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. 2022 Oct 19;23(20):12554.
doi: 10.3390/ijms232012554.

Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review

Dinah Farhanah Jamal  1 , Quratul Ain Rozaimee  1 , Nadila Haryani Osman  1 , Atikah Mohd Sukor  1 , Marjanu Hikmah Elias  1 , Nor Aripin Shamaan  1 , Srijit Das  2 , Nazefah Abdul Hamid  1
Affiliations

Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review

Dinah Farhanah Jamal et al. Int J Mol Sci. .

Abstract

Human papillomavirus type 16 (HPV-16) is a well-known etiological factor for cervical and oropharyngeal cancers. The E2 protein, the product of an early-transcribed gene in HPV-16, is postulated to cause the death of cancerous cells via p53-dependent and p53-independent pathways. The main aim of the present systematic review was to study the HPV 16-E2 protein as an apoptosis-inducer agent. A thorough search of MEDLINE/PubMed, Science Direct, Scopus, and EBSCOhost databases was conducted for relevant studies on HPV AND apoptosis OR cell death where HPV 16-E2 was involved. The search identified 967 publications. Eleven records dated from 1 January 1997 to 16 February 2022 were found to meet the inclusion criteria and were eligible for data extraction and inclusion. All studies concluded that HPV 16-E2 was able to induce cell death in transfected cells. E2 proteins from the high-risk HPV-16 were able to induce apoptosis through different apoptotic pathways depending on the location of the expressed gene. However, the mechanism was still unclear, and further studies are warranted.

Keywords: E2 protein; HPV 16; apoptosis; cell death; human papillomavirus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA used in the methods in the study. Total of records were 967 and a final of 11 studies were included.
See this image and copyright information in PMC

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