Intra- and Interrater Reliability of Short-Term Measurement of Heart Rate Variability on Rest in Individuals Post-COVID-19

doi:10.3390/ijerph192013587

. 2022 Oct 20;19(20):13587.

doi: 10.3390/ijerph192013587.

Intra- and Interrater Reliability of Short-Term Measurement of Heart Rate Variability on Rest in Individuals Post-COVID-19

Lucivalda Viegas de Almeida^{1

2}, Aldair Darlan Santos-de-Araújo^{3

4}, Rodrigo Costa Cutrim^{2

5}, Rudys Rodolfo de Jesus Tavarez⁵, Audrey Borghi-Silva^{3

4}, Fábio Henrique Ferreira Pereira^{2

6}, André Pontes-Silva³, Adriana Sousa Rêgo^{1

2

6

7

8}, Daniel Santos Rocha^{2

7}, Renan Shida Marinho^{3

4}, Almir Vieira Dibai-Filho^{8

9}, Daniela Bassi-Dibai^{1

2

5

6

7}

Affiliations

¹ Postgraduate Program in Programs Management and Health Services, Universidade Ceuma, São Luís 65075-120, MA, Brazil.
² Grupo de Pesquisa em Avaliação e Reabilitação Cardiovascular, Respiratória e Metabólica, Universidade Ceuma, São Luís 65075-120, MA, Brazil.
³ Department of Physical Therapy, Universidade Federal de São Carlos, São Carlos 13565-905, SP, Brazil.
⁴ Cardiopulmonary Physiotherapy Laboratory-LACAP, Universidade Federal de São Carlos, São Carlos 13565-905, SP, Brazil.
⁵ Postgraduate Program in Dentistry, Universidade Ceuma, São Luís 65075-120, MA, Brazil.
⁶ Postgraduate Program in Environment, Universidade Ceuma, São Luís 65075-120, MA, Brazil.
⁷ Department of Physical Therapy, Universidade Ceuma, São Luís 65075-120, MA, Brazil.
⁸ Postgraduate Program in Adult Health, Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil.
⁹ Grupo de Pesquisa em Reabilitação, Exercício e Movimento (REMOVI) Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil.

PMID: 36294172
PMCID: PMC9602575
DOI: 10.3390/ijerph192013587

Intra- and Interrater Reliability of Short-Term Measurement of Heart Rate Variability on Rest in Individuals Post-COVID-19

Lucivalda Viegas de Almeida et al. Int J Environ Res Public Health. 2022.

. 2022 Oct 20;19(20):13587.

doi: 10.3390/ijerph192013587.

Authors

Affiliations

¹ Postgraduate Program in Programs Management and Health Services, Universidade Ceuma, São Luís 65075-120, MA, Brazil.
² Grupo de Pesquisa em Avaliação e Reabilitação Cardiovascular, Respiratória e Metabólica, Universidade Ceuma, São Luís 65075-120, MA, Brazil.
³ Department of Physical Therapy, Universidade Federal de São Carlos, São Carlos 13565-905, SP, Brazil.
⁴ Cardiopulmonary Physiotherapy Laboratory-LACAP, Universidade Federal de São Carlos, São Carlos 13565-905, SP, Brazil.
⁵ Postgraduate Program in Dentistry, Universidade Ceuma, São Luís 65075-120, MA, Brazil.
⁶ Postgraduate Program in Environment, Universidade Ceuma, São Luís 65075-120, MA, Brazil.
⁷ Department of Physical Therapy, Universidade Ceuma, São Luís 65075-120, MA, Brazil.
⁸ Postgraduate Program in Adult Health, Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil.
⁹ Grupo de Pesquisa em Reabilitação, Exercício e Movimento (REMOVI) Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil.

PMID: 36294172
PMCID: PMC9602575
DOI: 10.3390/ijerph192013587

Abstract

Individuals affected by COVID-19 have an alteration in autonomic balance, associated with impaired cardiac parasympathetic modulation and, consequently, a decrease in heart rate variability (HRV). This study examines the inter- and intrarater reliability of HRV) parameters derived from short-term recordings in individuals post-COVID. Sixty-nine participants of both genders post-COVID were included. The RR interval, the time elapsed between two successive R-waves of the QRS signal on the electrocardiogram (RRi), were recorded during a 10 min period in a supine position using a portable heart rate monitor (Polar^® V800 model). The data were transferred into Kubios^® HRV standard analysis software and analyzed within the stable sessions containing 256 sequential RRi. The intraclass correlation coefficient (ICC) ranged from 0.920 to 1.000 according to the intrarater analysis by Researcher 01 and 0.959 to 0.999 according to the intrarater by Researcher 02. The interrater ICC ranged from 0.912 to 0.998. The coefficient of variation was up to 9.23 for Researcher 01 intrarater analysis, 6.96 for Researcher 02 intrarater analysis and 8.83 for interrater analysis. The measurement of HRV in post-COVID-19 individuals is reliable and presents a small amount of error inherent to the method, supporting its use in the clinical environment and in scientific research.

Keywords: COVID-19; Kubios Software; heart rate variability; reliability; reproducibility.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 2**
Bland-Altman plots for the RMSSD, LF and APEN intrarater and interrater.

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References

1. Shi S., Qin M., Shen B., Cai Y., Liu T., Yang F., Gong W., Liu X., Liang J., Zhao Q., et al. Association of Cardiac Injury with Mortality in Hospitalized Patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5:802–810. doi: 10.1001/jamacardio.2020.0950. - DOI - PMC - PubMed
1. Xu H., Hou K., Xu R., Li Z., Fu H., Wen L., Xie L., Liu H., Selvanayagam J.B., Zhang N., et al. Clinical Characteristics and Risk Factors of Cardiac Involvement in COVID-19. J. Am. Hear. Assoc. 2020;9:16807. doi: 10.1161/JAHA.120.016807. - DOI - PMC - PubMed
1. Frota A.X., Vieira M.C., Soares C.C.S., da Silva P.S., da Silva G.M.S., Mendes F.d.S.N.S., Mazzoli-Rocha F., Veloso H.H., da Costa A.D., Lamas C.d.C., et al. Functional Capacity and Rehabilitation Strategies in COVID-19 Patients: Current Knowledge and Challenges. Rev. Soc. Bras. Med. Trop. 2021;54:1–8. doi: 10.1590/0037-8682-0789-2020. - DOI - PMC - PubMed
1. Hasty F., García G., Dávila H., Wittels S.H., Hendricks S., Chong S. Heart Rate Variability as a Possible Predictive Marker for Acute Inflammatory Response in COVID-19 Patients. Mil. Med. 2021;186:e34–e38. doi: 10.1093/milmed/usaa405. - DOI - PMC - PubMed
1. Williams D.W.P., Koenig J., Carnevali L., Sgoifo A., Jarczok M.N., Sternberg E.M., Thayer J.F. Heart Rate Variability and Inflammation: A Meta-Analysis of Human Studies. Brain Behav. Immun. 2019;80:219–226. doi: 10.1016/j.bbi.2019.03.009. - DOI - PubMed

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[1] Shi S., Qin M., Shen B., Cai Y., Liu T., Yang F., Gong W., Liu X., Liang J., Zhao Q., et al. Association of Cardiac Injury with Mortality in Hospitalized Patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5:802–810. doi: 10.1001/jamacardio.2020.0950. - DOI - PMC - PubMed

[2] Shi S., Qin M., Shen B., Cai Y., Liu T., Yang F., Gong W., Liu X., Liang J., Zhao Q., et al. Association of Cardiac Injury with Mortality in Hospitalized Patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5:802–810. doi: 10.1001/jamacardio.2020.0950. - DOI - PMC - PubMed

[3] Xu H., Hou K., Xu R., Li Z., Fu H., Wen L., Xie L., Liu H., Selvanayagam J.B., Zhang N., et al. Clinical Characteristics and Risk Factors of Cardiac Involvement in COVID-19. J. Am. Hear. Assoc. 2020;9:16807. doi: 10.1161/JAHA.120.016807. - DOI - PMC - PubMed

[4] Xu H., Hou K., Xu R., Li Z., Fu H., Wen L., Xie L., Liu H., Selvanayagam J.B., Zhang N., et al. Clinical Characteristics and Risk Factors of Cardiac Involvement in COVID-19. J. Am. Hear. Assoc. 2020;9:16807. doi: 10.1161/JAHA.120.016807. - DOI - PMC - PubMed

[5] Frota A.X., Vieira M.C., Soares C.C.S., da Silva P.S., da Silva G.M.S., Mendes F.d.S.N.S., Mazzoli-Rocha F., Veloso H.H., da Costa A.D., Lamas C.d.C., et al. Functional Capacity and Rehabilitation Strategies in COVID-19 Patients: Current Knowledge and Challenges. Rev. Soc. Bras. Med. Trop. 2021;54:1–8. doi: 10.1590/0037-8682-0789-2020. - DOI - PMC - PubMed

[6] Frota A.X., Vieira M.C., Soares C.C.S., da Silva P.S., da Silva G.M.S., Mendes F.d.S.N.S., Mazzoli-Rocha F., Veloso H.H., da Costa A.D., Lamas C.d.C., et al. Functional Capacity and Rehabilitation Strategies in COVID-19 Patients: Current Knowledge and Challenges. Rev. Soc. Bras. Med. Trop. 2021;54:1–8. doi: 10.1590/0037-8682-0789-2020. - DOI - PMC - PubMed

[7] Hasty F., García G., Dávila H., Wittels S.H., Hendricks S., Chong S. Heart Rate Variability as a Possible Predictive Marker for Acute Inflammatory Response in COVID-19 Patients. Mil. Med. 2021;186:e34–e38. doi: 10.1093/milmed/usaa405. - DOI - PMC - PubMed

[8] Hasty F., García G., Dávila H., Wittels S.H., Hendricks S., Chong S. Heart Rate Variability as a Possible Predictive Marker for Acute Inflammatory Response in COVID-19 Patients. Mil. Med. 2021;186:e34–e38. doi: 10.1093/milmed/usaa405. - DOI - PMC - PubMed

[9] Williams D.W.P., Koenig J., Carnevali L., Sgoifo A., Jarczok M.N., Sternberg E.M., Thayer J.F. Heart Rate Variability and Inflammation: A Meta-Analysis of Human Studies. Brain Behav. Immun. 2019;80:219–226. doi: 10.1016/j.bbi.2019.03.009. - DOI - PubMed

[10] Williams D.W.P., Koenig J., Carnevali L., Sgoifo A., Jarczok M.N., Sternberg E.M., Thayer J.F. Heart Rate Variability and Inflammation: A Meta-Analysis of Human Studies. Brain Behav. Immun. 2019;80:219–226. doi: 10.1016/j.bbi.2019.03.009. - DOI - PubMed

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Intra- and Interrater Reliability of Short-Term Measurement of Heart Rate Variability on Rest in Individuals Post-COVID-19

Affiliations

Intra- and Interrater Reliability of Short-Term Measurement of Heart Rate Variability on Rest in Individuals Post-COVID-19

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical