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. 2022 Oct 11;11(20):5982.
doi: 10.3390/jcm11205982.

Echocardiographic Abnormalities in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients

Mariana Becker Pfeferman  1   2 , Daniel Ribeiro da Rocha  2 , Fernanda Guedes Rodrigues  3 , Elcio Pfeferman  4 , Ita Pfeferman Heilberg  2
Affiliations

Echocardiographic Abnormalities in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients

Mariana Becker Pfeferman et al. J Clin Med. .

Abstract

Cardiovascular abnormalities, such as left ventricular hypertrophy and valvular disorders, particularly mitral valve prolapse, have been described as highly prevalent among adult patients with autosomal dominant polycystic kidney disease (ADPKD). The present study aimed to assess echocardiographic parameters in a large sample of both normotensive and hypertensive ADPKD patients, regardless of kidney function level, and evaluate their association with clinical and laboratorial parameters. A retrospective study consisted of the analysis of clinical, laboratorial, and transthoracic echocardiograms data retrieved from the medical records of young adult ADPKD outpatients. A total of 294 patients (120 M/174 F, 41.0 ± 13.8 years old, 199 hypertensive and 95 normotensive) with a median estimated glomerular filtration rate (eGFR) of 75.5 mL/min/1.73 m2 were included. The hypertensive group (67.6%) was significantly older and exhibited significantly lower eGFR than the normotensive one. Increased left ventricular mass index (LVMI) was seen in 2.0%, mitral valve prolapse was observed in 3.4%, mitral valve regurgitation in 15.3%, tricuspid valve regurgitation in 16.0%, and aortic valve regurgitation in 4.8% of the whole sample. The present study suggested that the prevalence of mitral valve prolapse was much lower than previously reported, and increased LVMI was not seen in most adult ADPKD patients.

Keywords: ADPKD; cardiovascular; echocardiogram; left ventricular mass index; mitral valve prolapse; polycystic disease; valvar abnormalities.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study, collection, analysis or interpretation of data and in the writing of the manuscript.

Figures

Figure 1
Figure 1
Valvar abnormalities.
See this image and copyright information in PMC

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