Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct 18;11(20):6129.
doi: 10.3390/jcm11206129.

Pulmonary Embolism Response Teams: Theory, Implementation, and Unanswered Questions

Affiliations
Review

Pulmonary Embolism Response Teams: Theory, Implementation, and Unanswered Questions

Antoine Bejjani et al. J Clin Med. .

Abstract

Pulmonary embolism (PE) continues to represent a significant health care burden and its incidence is steadily increasing worldwide. Constantly evolving therapeutic options and the rarity of randomized controlled trial data to drive clinical guidelines impose challenges on physicians caring for patients with PE. Recently, PE response teams have been developed and recommended to help address these issues by facilitating a consensus among local experts while advocating the management of acute PE according to each individual patient profile. In this review, we focus on the clinical challenges supporting the need for a PE response team, report the current evidence for their implementation, assess their impact on PE management and outcomes, and address unanswered questions and future directions.

Keywords: catheter-directed therapy; length of stay; pulmonary embolism; pulmonary embolism response team.

PubMed Disclaimer

Conflict of interest statement

Piazza has received research support from Bristol-Myers Squibb/Pfizer Alliance, Bayer, Janssen, Alexion, Amgen and Boston Scientific Corporation, and consulting fees from Bristol-Myers Squibb/Pfizer Alliance, Boston Scientific Corporation, Janssen, Namsa, Prairie Education and Research Cooperative, Boston Clinical Research Institute, and Amgen. The other authors report no conflicts of interest.

Figures

Figure 1
Figure 1
The rationale for pulmonary embolism response teams.
Figure 2
Figure 2
The rationale for a PE response team. PE = pulmonary embolism.
Figure 3
Figure 3
Structure and development of a PE response team. PE = pulmonary embolism.

References

    1. Tsao C.W., Aday A.W., Almarzooq Z.I., Alonso A., Beaton A.Z., Bittencourt M.S., Boehme A.K., Buxton A.E., Carson A.P., Commodore-Mensah Y., et al. Heart Disease and Stroke Statistics—2022 Update: A Report from the American Heart Association. Circulation. 2022;145:e153–e639. doi: 10.1161/CIR.0000000000001052. - DOI - PubMed
    1. Pollack C.V., Schreiber D., Goldhaber S.Z., Slattery D., Fanikos J., O’Neil B.J., Thompson J.R., Hiestand B., Briese B.A., Pendleton R.C., et al. Clinical Characteristics, Management, and Outcomes of Patients Diagnosed with Acute Pulmonary Embolism in the Emergency Department: Initial Report of EMPEROR (Multicenter Emergency Medicine Pulmonary Embolism in the Real World Registry) J. Am. Coll. Cardiol. 2011;57:700–706. doi: 10.1016/j.jacc.2010.05.071. - DOI - PubMed
    1. Jiménez D., de Miguel-Díez J., Guijarro R., Trujillo-Santos J., Otero R., Barba R., Muriel A., Meyer G., Yusen R.D., Monreal M. Trends in the Management and Outcomes of Acute Pulmonary Embolism: Analysis from the RIETE Registry. J. Am. Coll. Cardiol. 2016;67:162–170. doi: 10.1016/j.jacc.2015.10.060. - DOI - PubMed
    1. Martin K.A., Molsberry R., Cuttica M.J., Desai K.R., Schimmel D.R., Khan S.S. Time Trends in Pulmonary Embolism Mortality Rates in the United States, 1999 to 2018. J. Am. Heart Assoc. 2020;9:e016784. doi: 10.1161/JAHA.120.016784. - DOI - PMC - PubMed
    1. Barco S., Valerio L., Ageno W., Cohen A.T., Goldhaber S.Z., Hunt B.J., Iorio A., Jimenez D., Klok F.A., Kucher N., et al. Age-sex specific pulmonary embolism-related mortality in the USA and Canada, 2000–2018: An analysis of the WHO Mortality Database and of the CDC Multiple Cause of Death database. Lancet Respir. Med. 2020;9:33–42. doi: 10.1016/S2213-2600(20)30417-3. - DOI - PMC - PubMed

LinkOut - more resources