Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct 18;11(20):6135.
doi: 10.3390/jcm11206135.

Cannabis Use Is Inversely Associated with Metabolic Disorders in Hepatitis C-Infected Patients (ANRS CO22 Hepather Cohort)

Tangui Barré  1 , Marc Bourlière  1   2 , Clémence Ramier  1 , Fabrice Carrat  3   4 , Vincent Di Beo  1 , Camelia Protopopescu  1 , Fabienne Marcellin  1 , Morgane Bureau  1 , Carole Cagnot  5 , Céline Dorival  3 , Fabien Zoulim  6   7   8 , Jessica Zucman-Rossi  9   10 , Jean-Charles Duclos-Vallée  11 , Hélène Fontaine  12 , Patrizia Carrieri  1 , The Anrs/Afef Hepather Study Group
Affiliations

Cannabis Use Is Inversely Associated with Metabolic Disorders in Hepatitis C-Infected Patients (ANRS CO22 Hepather Cohort)

Tangui Barré et al. J Clin Med. .

Abstract

Background and aims: Hepatitis C virus (HCV) infection is associated with the onset of metabolic disorders which constitute risk factors for liver disease progression. Their impact may persist after the HCV infection has been cured. Cannabis use is associated with a lower risk of obesity and diabetes in both general and HCV populations. The associations between cannabis use and both dyslipidemia and hypertension have not yet been studied in persons with chronic HCV infection.

Methods: Using cross-sectional data from the French ANRS CO22 Hepather cohort, we used regression models to test for an inverse relationship between cannabis use and (i) dyslipidemia, (ii) hypertension, and (iii) the total number of metabolic disorders.

Results: Among the 6364 participants in the study population, both former and current cannabis use were associated with a lower risk of hypertension and fewer metabolic disorders. These results were independent of central obesity. Cannabis use was not associated with dyslipidemia.

Conclusions: In people chronically infected with HCV, cannabis use was associated with a lower risk of hypertension and a lower number of metabolic disorders. Post-HCV cure studies are needed to confirm these findings using longitudinal data and to test whether they translate into reduced mortality in this population.

Keywords: cannabis; chronic; dyslipidemia; hepatitis C; hypertension; metabolic syndrome.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Flow chart of the study population (ANRS CO22 Hepather cohort).
See this image and copyright information in PMC

References

    1. Wang C.-C., Cheng P.-N., Kao J.-H. Systematic review: Chronic viral hepatitis and metabolic derangement. Aliment. Pharmacol. Ther. 2020;51:216–230. doi: 10.1111/apt.15575. - DOI - PubMed
    1. Kuo Y.-H., Kee K.-M., Wang J.-H., Hsu N.-T., Hsiao C.-C., Chen Y., Lu S.-N. Association between chronic viral hepatitis and metabolic syndrome in southern Taiwan: A large population-based study. Aliment. Pharmacol. Ther. 2018;48:993–1002. doi: 10.1111/apt.14960. - DOI - PubMed
    1. Chang M.-L. Metabolic alterations and hepatitis C: From bench to bedside. World J. Gastroenterol. 2016;22:1461–1476. doi: 10.3748/wjg.v22.i4.1461. - DOI - PMC - PubMed
    1. Alberti K.G.M.M., Eckel R.H., Grundy S.M., Zimmet P.Z., Cleeman J.I., Donato K.A., Fruchart J.-C., James W.P.T., Loria C.M., Smith S.C., Jr., et al. Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640–1645. - PubMed
    1. McPherson S., Gosrani S., Hogg S., Patel P., Wetten A., Welton R., Hallsworth K., Campbell M. Increased cardiovascular risk and reduced quality of life are highly prevalent among individuals with hepatitis C. BMJ Open Gastroenterol. 2020;7:e000470. doi: 10.1136/bmjgast-2020-000470. - DOI - PMC - PubMed

LinkOut - more resources