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. 2022 Oct 5;12(10):1659.
doi: 10.3390/jpm12101659.

Design of a Functional Eye Dressing for Treatment of the Vitreous Floater

Wen-Shuang Fan  1 , Shuan-Yu Huang  2 , Hong-Thai Nguyen  3 , Wen-Tsung Ho  4   5 , Wen-Hung Chao  4 , Fen-Chi Lin  6 , Hsiang-Chen Wang  3
Affiliations

Design of a Functional Eye Dressing for Treatment of the Vitreous Floater

Wen-Shuang Fan et al. J Pers Med. .

Abstract

With the rapid development of display technology, related diseases of the human eye are also increasing day by day. Eye floaters are one of the diseases that affect humans. Herein, we present a functional ophthalmic dressing that can permeate the skin tissues of the eyes through oxygen and hydrogen to improve the symptoms of floaters. In clinical tests, the symptoms of sensory floaters improved in 28 patients, and the recovery rates of mild, moderate, and severe floaters were about 70%, 66.7%, and 83.3%, respectively.

Keywords: eye floaters; functional eye dressing; hydrogen therapy; oxygen therapy; vitreous floaters.

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Conflict of interest statement

The authors declare no conflicts of interest

Figures

Figure 1
Figure 1
Oxygen repair cell derivation process. (a) Synthesis of adenosine triphosphate (ATP), collagen, protein, phagocytes, and oxygen. (b) Enzyme-catalyzed redox repair in the cell. (c) Hyperbaric oxygen therapeutic cell repair. (d) Synthesis of nitric oxide (NO) angiogenesis. Vascular endothelial growth factor (VEGF).
Figure 2
Figure 2
Biological effect mechanism of hydrogen. (a) H2 selective removal of -OH and ONOO−. (b) H2 stimulating human apoptosis factor cell regulation. (c) H2 promoting human inflammatory factor cell regulation. (d) Unknown molecular mechanism of H2 regulation.
Figure 3
Figure 3
Structure of the functional dressing. The outer film layer has a structure that allows the penetration of H2O easily, the middle layer consists of chemical compounds that generate hydrogen and oxygen, and sequentially escape through the inner film layer.
Figure 4
Figure 4
Measurement results of B-type ultrasound scanner. (a–c) Imaging analysis of mild, moderate, and severe floaters, respectively. The figure on the right is the OCT in the horizontal and vertical directions.
Figure 5
Figure 5
Comparative analysis of clinical treatment effects. Results showed improvement of eye floaters symptoms through fading of macular shadows and floating objects compared to baseline disease (a,d), after 2 months of treatment (b,e), and after 4 months of treatment (c,f) of 2 patients A and B.
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