. 2022 Oct 8;12(10):1672.

doi: 10.3390/jpm12101672.

Clinical Significance of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer

Nikolaos Garmpis^{1

2}, Christos Damaskos^{2

3}, Dimitrios Dimitroulis¹, Gregory Kouraklis⁴, Anna Garmpi⁵, Panagiotis Sarantis⁶, Evangelos Koustas⁶, Alexandros Patsouras⁷, Iason Psilopatis⁸, Efstathios A Antoniou^{1

2}, Michail V Karamouzis⁶, Konstantinos Kontzoglou^{1

2}, Afroditi Nonni⁹

Affiliations

¹ Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
² N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
³ Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece.
⁴ Department of Surgery, Evgenideio Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁵ First Department of Propedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁶ Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁷ Second Department of Pulmonology, Sotiria General Hospital, 11527 Athens, Greece.
⁸ Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
⁹ First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

PMID: 36294811
PMCID: PMC9604828
DOI: 10.3390/jpm12101672

Clinical Significance of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer

Nikolaos Garmpis et al. J Pers Med. 2022.

. 2022 Oct 8;12(10):1672.

doi: 10.3390/jpm12101672.

Authors

Affiliations

¹ Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
² N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
³ Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece.
⁴ Department of Surgery, Evgenideio Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁵ First Department of Propedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁶ Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁷ Second Department of Pulmonology, Sotiria General Hospital, 11527 Athens, Greece.
⁸ Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
⁹ First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

PMID: 36294811
PMCID: PMC9604828
DOI: 10.3390/jpm12101672

Abstract

Background/aim: There is a strong association between malignancy and histone deacetylases (HDACs). Histone deacetylase inhibitors (HDACIs) are now being tested as antitumor agents in various clinical trials. We aimed to assess the clinical importance of HDAC-2 in breast cancer (BC).

Materials and methods: A total of 118 BC specimens were examined immunohistochemically. A statistical analysis was conducted in order to examine the relation between HDAC-2 and the clinicopathological features and survival of the patients.

Results: Higher HDAC-2 expression was related to lobular histological type of cancer, grade III, and stage III BC. In addition, the disease-free period and overall survival were curtailed and negatively related to the over-expression of HDAC-2. Other factors correlating with worse survival were histological types other than ductal or lobular, and the stage of the disease.

Conclusions: This study showed a relationship between HDAC-2 and BC. Further studies are required in order to eventually potentiate the role of HDACIs as anticancer agents in BC.

Keywords: HDAC; breast; cancer; clinicopathological; deacetylase; histone.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Histone deacetylases’ function and classification.

**Scheme 1**
Patient selection criteria and flow chart of the current study.

**Figure 2**
HDAC-2 immunohistochemical expression in breast cancer tissue (×400). (A): Negative nuclear staining. (B): Mild to moderate nuclear staining. (C): Strong nuclear staining.

**Figure 3**
Kaplan–Meier estimates for survival according to HDAC-2 immunohistochemical expression. (A): Disease-free survival. (B): Overall survival.

See this image and copyright information in PMC

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Clinical Significance of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer

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Clinical Significance of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer

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Abstract

Conflict of interest statement

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Abstract

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