Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center

Camilla Nero^{1

2}, Simona Duranti³, Flavia Giacomini³, Angelo Minucci⁴, Luciano Giacò⁵, Alessia Piermattei⁶, Maurizio Genuardi^{2

7}, Tina Pasciuto⁸, Andrea Urbani^{2

9}, Gennaro Daniele¹⁰, Domenica Lorusso^{1

2}, Raffaele Pignataro¹¹, Giampaolo Tortora^{2

12}, Nicola Normanno¹³, Giovanni Scambia^{1

2}

Affiliations

¹ Dipartimento per le Scienze Della Salute Della Donna, del Bambino e di Sanità Pubblica, UOC Ginecologia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
² Faculty of Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
³ Direzione Scientifica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁴ Genomics Core Facility, Gemelli Science and Technology Park (G-STeP), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁵ Bioinformatics Core Facility, Gemelli Science and Technology Park (G-STeP), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁶ Dipartimento per le Scienze Della Salute Della Donna, del Bambino e di Sanità Pubblica, UOC Anatomia Patologica Generale, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁷ Dipartimento per le Scienze di Laboratorio e Infettivologiche, UOC Genetica Medica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁸ Data Collection Core Facility, Gemelli Science and Technology Park (G-STeP), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁹ Dipartimento per le Scienze di Laboratorio e Infettivologiche, UOC Chimica, Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
¹⁰ UOC Fase 1, Direzione Scientifica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
¹¹ Direzione Sanitaria, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
¹² Dipartimento di Scienze Mediche e Chirurgiche, UOC Oncologica Medica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
¹³ Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori "Fondazione Giovanni Pascale", IRCCS, 80131 Napoli, Italy.

PMID: 36294885
PMCID: PMC9605534
DOI: 10.3390/jpm12101746

Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center

Camilla Nero et al. J Pers Med. 2022.

. 2022 Oct 20;12(10):1746.

doi: 10.3390/jpm12101746.

Authors

Affiliations

¹ Dipartimento per le Scienze Della Salute Della Donna, del Bambino e di Sanità Pubblica, UOC Ginecologia Oncologica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
² Faculty of Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
³ Direzione Scientifica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁴ Genomics Core Facility, Gemelli Science and Technology Park (G-STeP), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁵ Bioinformatics Core Facility, Gemelli Science and Technology Park (G-STeP), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁶ Dipartimento per le Scienze Della Salute Della Donna, del Bambino e di Sanità Pubblica, UOC Anatomia Patologica Generale, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁷ Dipartimento per le Scienze di Laboratorio e Infettivologiche, UOC Genetica Medica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁸ Data Collection Core Facility, Gemelli Science and Technology Park (G-STeP), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
⁹ Dipartimento per le Scienze di Laboratorio e Infettivologiche, UOC Chimica, Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
¹⁰ UOC Fase 1, Direzione Scientifica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
¹¹ Direzione Sanitaria, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
¹² Dipartimento di Scienze Mediche e Chirurgiche, UOC Oncologica Medica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
¹³ Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori "Fondazione Giovanni Pascale", IRCCS, 80131 Napoli, Italy.

PMID: 36294885
PMCID: PMC9605534
DOI: 10.3390/jpm12101746

Abstract

The implementation of cancer molecular characterization in clinical practice has improved prognostic re-definition, extending the eligibility to a continuously increasing number of targeted treatments. Broad molecular profiling technologies better than organ-based approaches are believed to serve such dynamic purposes. We here present the workflow our institution adopted to run a comprehensive cancer genome profiling in clinical practice. This article describes the workflow designed to make a comprehensive cancer genome profiling program feasible and sustainable in a large-volume referral hospital.

Keywords: bioinformatics; cancer; comprehensive cancer genome profiling; genomics; target therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

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Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center

Affiliations

Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center

Authors

Affiliations

Abstract

Conflict of interest statement

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