Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct 11;58(10):1434.
doi: 10.3390/medicina58101434.

Viability Criteria during Liver Ex-Situ Normothermic and Hypothermic Perfusion

Fabio Melandro  1 , Riccardo De Carlis  2 , Francesco Torri  1 , Andrea Lauterio  2   3   4 , Paolo De Simone  3 , Luciano De Carlis  2   3   4 , Davide Ghinolfi  1
Affiliations
Review

Viability Criteria during Liver Ex-Situ Normothermic and Hypothermic Perfusion

Fabio Melandro et al. Medicina (Kaunas). .

Abstract

With the increased use of extended-criteria donors, machine perfusion became a beneficial alternative to cold storage in preservation strategy for donor livers with the intent to expand donor pool. Both normothermic and hypothermic approach achieved good results in terms of mid- and long-term outcome in liver transplantation. Many markers and molecules have been proposed for the assessment of liver, but no definitive criteria for graft viability have been validated in large clinical trials and key parameters during perfusion still require optimization.In this review, we address the current literature of viability criteria during normothermic and hypothermic machine perfusion and discuss about future steps and evolution of these technologies.

Keywords: hypothermic machine perfusion; liver transplantation; machine perfusion; normothermic machine perfusion; viability criteria.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interests to be reported.

Figures

Figure 1
Figure 1
Prisma.
See this image and copyright information in PMC

References

    1. Ghinolfi D., Pezzati D., Rreka E., Balzano E., Catalano G., Coletti L., Tincani G., Carrai P., Petruccelli S., Martinelli C., et al. Nonagenarian grafts for liver transplantation. Liver Transplant. 2019;25:1439–1444. doi: 10.1002/lt.25580. - DOI - PubMed
    1. Biancofiore G., Bindi M., Ghinolfi D., Lai Q., Bisa M., Esposito M., Meacci L., Mozzo R., Spelta A., Filipponi F. Octogenarian donors in liver transplantation grant an equivalent perioperative course to ideal young donors. Dig. Liver Dis. 2017;49:676–682. doi: 10.1016/j.dld.2017.01.149. - DOI - PubMed
    1. Pezzati D., Ghinolfi D., Balzano E., De Simone P., Coletti L., Roffi N., Rreka E., Meacci L., Campani D., Mazzoni A., et al. Salvage of an octogenarian liver graft using normothermic perfusion: A case report. Transplant. Proc. 2017;49:726–728. doi: 10.1016/j.transproceed.2017.02.014. - DOI - PubMed
    1. Ghinolfi D., Lai Q., Dondossola D., De Carlis R., Zanierato M., Patrono D., Baroni S., Bassi D., Ferla F., Lauterio A., et al. Machine perfusions in liver transplantation: The evidence-based position paper of the italian society of organ and tissue transplantation. Liver Transplant. 2020;26:1298–1315. doi: 10.1002/lt.25817. - DOI - PubMed
    1. Page M.J., McKenzie J.E., Bossuyt P.M., Boutron I., Hoffmann T.C., Mulrow C.D., Shamseer L., Tetzlaff J.M., Akl E.A., Brennan S.E., et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi: 10.1136/bmj.n71. - DOI - PMC - PubMed