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Review
. 2022 Sep 23;12(10):897.
doi: 10.3390/metabo12100897.

Impact of Micro- and Nanoplastics on Mitochondria

Seung Eun Lee  1 , Yoojung Yi  2 , Sangji Moon  2 , Hyunkyung Yoon  2 , Yong Seek Park  1
Affiliations
Review

Impact of Micro- and Nanoplastics on Mitochondria

Seung Eun Lee et al. Metabolites. .

Abstract

Mitochondria are highly dynamic cellular organelles that perform crucial functions such as respiration, energy production, metabolism, and cell fate decisions. Mitochondrial damage and dysfunction critically lead to the pathogenesis of various diseases including cancer, diabetes, and neurodegenerative and cardiovascular disorders. Mitochondrial damage in response to environmental contaminant exposure and its association with the pathogenesis of diseases has also been reported. Recently, persistent pollutants, such as micro- and nanoplastics, have become growing global environmental threats with potential health risks. In this review, we discuss the impact of micro- and nanoplastics on mitochondria and review current knowledge in this field.

Keywords: environmental contaminants; micro- and nanoplastics; mitochondria; toxicity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Environmental contaminant-induced mitochondrial dysfunction may lead to various diseases.
Figure 2
Figure 2
Sources of micro- and nanoplastics in the environment.
Figure 3
Figure 3
Role of mitochondria in response to micro- and nanoplastics toxicity.
See this image and copyright information in PMC

References

    1. Archibald J.M. Endosymbiosis and Eukaryotic Cell Evolution. Curr. Biol. 2015;25:R911–R921. doi: 10.1016/j.cub.2015.07.055. - DOI - PubMed
    1. Gray M.W. Mitochondrial evolution. Cold Spring Harb. Perspect. Biol. 2012;4:a011403. doi: 10.1101/cshperspect.a011403. - DOI - PMC - PubMed
    1. Kurland C.G., Andersson S.G.E. Origin and evolution of the mitochondrial proteome. Microbiol. Mol. Biol. Rev. 2000;64:786–820. doi: 10.1128/MMBR.64.4.786-820.2000. - DOI - PMC - PubMed
    1. Javadov S., Kozlov A.V., Camara A.K.S. Mitochondria in Health and Diseases. Cells. 2020;9:1177. doi: 10.3390/cells9051177. - DOI - PMC - PubMed
    1. Kroemer G., Galluzzi L., Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 2007;87:99–163. doi: 10.1152/physrev.00013.2006. - DOI - PubMed

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