Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct 21;27(20):7119.
doi: 10.3390/molecules27207119.

Phytochemical Composition and In Vitro Antioxidant, Anti-Inflammatory, Anticancer, and Enzyme-Inhibitory Activities of Artemisia nilagirica (C.B. Clarke) Pamp

Jawaher J Albaqami  1 , Tancia P Benny  2 , Hamida Hamdi  1   3 , Ammar B Altemimi  4   5 , Aswathi Moothakoottil Kuttithodi  2 , Joice Tom Job  2 , Anju Sasidharan  2 , Arunaksharan Narayanankutty  2
Affiliations

Phytochemical Composition and In Vitro Antioxidant, Anti-Inflammatory, Anticancer, and Enzyme-Inhibitory Activities of Artemisia nilagirica (C.B. Clarke) Pamp

Jawaher J Albaqami et al. Molecules. .

Abstract

Plants have been employed in therapeutic applications against various infectious and chronic diseases from ancient times. Various traditional medicines and folk systems have utilized numerous plants and plant products, which act as sources of drug candidates for modern medicine. Artemisia is a genus of the Asteraceae family with more than 500 species; however, many of these species are less explored for their biological efficacy, and several others are lacking scientific explanations for their uses. Artemisia nilagirica is a plant that is widely found in the Western Ghats, Kerala, India and is a prominent member of the genus. In the current study, the phytochemical composition and the antioxidant, enzyme-inhibitory, anti-inflammatory, and anticancer activities were examined. The results indicated that the ethanol extract of A. nilagirica indicated in vitro DPPH scavenging (23.12 ± 1.28 µg/mL), ABTS scavenging (27.44 ± 1.88 µg/mL), H2O2 scavenging (12.92 ± 1.05 µg/mL), and FRAP (5.42 ± 0.19 µg/mL). The anti-inflammatory effect was also noticed in the Raw 264.7 macrophages, where pretreatment with the extract reduced the LPS-stimulated production of cytokines (p < 0.05). A. nilagirica was also efficient in inhibiting the activities of α-amylase (38.42 ± 2.71 µg/mL), α-glucosidase (55.31 ± 2.16 µg/mL), aldose reductase (17.42 ± 0.87 µg/mL), and sorbitol dehydrogenase (29.57 ± 1.46 µg/mL). It also induced significant inhibition of proliferation in breast (MCF7 IC50 = 41.79 ± 1.07, MDAMB231 IC50 = 55.37 ± 2.11µg/mL) and colon (49.57 ± 1.46 µg/mL) cancer cells. The results of the phytochemical screening indicated a higher level of polyphenols and flavonoids in the extract and the LCMS analysis revealed the presence of various bioactive constituents including artemisinin.

Keywords: Artemisia nilagirica; Asteraceae; anti-inflammatory activity; anticancer activity; antioxidant; phytochemistry.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The LC-MS total ion chromatogram of the A. nilagirica extract.
Figure 2
Figure 2
The anticancer potentials of the leaf extract of A. nilagirica (a) and cyclophosphamide (b).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Behera N.K., Mahalakshmi G.S. A cloud based knowledge discovery framework, for medicinal plants from PubMed literature. Inform. Med. Unlocked. 2019;16:100105. doi: 10.1016/j.imu.2018.04.006. - DOI
    1. Karpavičienė B. Traditional Uses of Medicinal Plants in South-Western Part of Lithuania. Plants. 2022;11:2093. doi: 10.3390/plants11162093. - DOI - PMC - PubMed
    1. Noor F., Tahir ul Qamar M., Ashfaq U.A., Albutti A., Alwashmi A.S.S., Aljasir M.A. Network Pharmacology Approach for Medicinal Plants: Review and Assessment. Pharmaceuticals. 2022;15:572. doi: 10.3390/ph15050572. - DOI - PMC - PubMed
    1. Adeleke B.S., Babalola O.O. Pharmacological Potential of Fungal Endophytes Associated with Medicinal Plants: A Review. J. Fungi. 2021;7:147. doi: 10.3390/jof7020147. - DOI - PMC - PubMed
    1. Septembre-Malaterre A., Lalarizo Rakoto M., Marodon C., Bedoui Y., Nakab J., Simon E., Hoarau L., Savriama S., Strasberg D., Guiraud P., et al. Artemisia annua, a Traditional Plant Brought to Light. Int. J. Mol. Sci. 2020;21:4986. doi: 10.3390/ijms21144986. - DOI - PMC - PubMed

LinkOut - more resources