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Review
. 2022 Oct 17;14(20):4353.
doi: 10.3390/nu14204353.

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Xiaoying Cui  1   2 , Darryl W Eyles  1   2
Affiliations
Review

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Xiaoying Cui et al. Nutrients. .

Abstract

Twenty of the last one hundred years of vitamin D research have involved investigations of the brain as a target organ for this hormone. Our group was one of the first to investigate brain outcomes resulting from primarily restricting dietary vitamin D during brain development. With the advent of new molecular and neurochemical techniques in neuroscience, there has been increasing interest in the potential neuroprotective actions of vitamin D in response to a variety of adverse exposures and how this hormone could affect brain development and function. Rather than provide an exhaustive summary of this data and a listing of neurological or psychiatric conditions that vitamin D deficiency has been associated with, here, we provide an update on the actions of this vitamin in the brain and cellular processes vitamin D may be targeting in psychiatry and neurology.

Keywords: brain; development; disease mechanisms; neuroprotection; vitamin D deficiency.

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Conflict of interest statement

The authors have no conflicts of interest.

Figures

Figure 1
Figure 1
Neuroprotective actions of vitamin D in brain.
See this image and copyright information in PMC

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