Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct 17;14(10):2280.
doi: 10.3390/v14102280.

Serological Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and IgM Positivity Were Identified in Healthy Residents in Vietnam

Xuan Chuong Tran  1 , Sung Hye Kim  2 , Jeong-Eun Lee  3 , So-Hee Kim  4 , Su Yeon Kang  2 , Nguyen D Binh  1 , Pham V Duc  1 , Phan T K Phuong  1 , Nguyen T P Thao  1 , Wonwoo Lee  2 , Joon-Yong Bae  3 , Man-Seong Park  3 , Misun Kim  5 , Jeong Rae Yoo  5 , Sang Taek Heo  5 , Kyeong Ho An  6 , Jung Mogg Kim  2 , Nam-Hyuk Cho  4 , Sun-Ho Kee  3 , Keun Hwa Lee  2
Affiliations

Serological Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and IgM Positivity Were Identified in Healthy Residents in Vietnam

Xuan Chuong Tran et al. Viruses. .

Abstract

Severe fever with thrombocytopenia syndrome (SFTS), an emerging tick-borne viral disease, is prevalent in East Asia and has also been reported in Southeast Asia since 2019. SFTS patients in Vietnam were first reported in 2019. However, the seroprevalence of severe fever with thrombocytopenia syndrome virus (SFTSV) in Vietnam has not been reported. To investigate the seroprevalence of SFTSV in Vietnam, we collected serum samples from 714 healthy residents in Thua Thien Hue and Quang Nam Province, Vietnam, and the seroprevalence of SFTSV was assessed using immunofluorescence antibody assay (IFA), Enzyme-Linked Immunosorbent Assays (ELISAs) and the 50% focus reduction neutralization test (FRNT50) assay. The seroprevalence of anti-SFTSV IgM or IgG was observed to be 3.64% (26/714), high IgM positivity was >80 (0.28%, 2/714) and the titer of neutralizing antibodies against SFTSV ranged from 15.5 to 55.9. In Pakistan, SFTSV infection confirmed using a microneutralization test (MNT) assay (prevalence is 2.5%) and ELISAs showed a high seroprevalence (46.7%) of SFTSV. Hence, the seroprevalence rate in Vietnam is similar to that in Pakistan and the number of SFTS patients could increase in Vietnam.

Keywords: IgM positivity; Vietnam; healthy residents; serological evidence; severe fever with thrombocytopenia syndrome virus (SFTSV).

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Immunofluorescence assay for IgG and IgM in healthy residents in Vietnam. Serum dilution: 1:80.
See this image and copyright information in PMC

References

    1. Yu X.J., Liang M.F., Zhang S.Y., Liu Y., Li J.D., Sun Y.L., Zhang L., Zhang Q.F., Popov V.L., Li C., et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N. Engl. J. Med. 2011;364:1523–1532. doi: 10.1056/NEJMoa1010095. - DOI - PMC - PubMed
    1. Yoo J.R., Heo S.T., Park D., Kim H., Fukuma A., Fukushi S., Shimojima M., Lee K.H. Family Cluster Analysis of Severe Fever with Thrombocytopenia Syndrome Virus Infection in Korea. Am. J. Trop. Med. Hyg. 2017;95:1351–1357. doi: 10.4269/ajtmh.16-0527. - DOI - PMC - PubMed
    1. Du Y., Cheng N., Li Y., Wang H., You A., Su J., Nie Y., Ma H., Xu B., Huang X. Seroprevalance of antibodies specific for severe fever with thrombocytopenia syndrome virus and the discovery of asymptomatic infections in Henan Province, China. PLoS Negl. Trop. Dis. 2019;13:e0007242. doi: 10.1371/journal.pntd.0007242. - DOI - PMC - PubMed
    1. Xiong W.Y., Feng Z.J., Matsui T., Foxwell A.R. Risk assessment of human infection with a novel bunyavirus in China. West. Pac. Surveill. Response J. 2012;3:61–66. doi: 10.5365/wpsar.2012.3.4.002. - DOI - PMC - PubMed
    1. Liu S., Chai C., Wang C., Amer S., Lv H., He H., Sun J., Lin J. Systematic review of severe fever with thrombocytopenia syndrome: Virology, epidemiology, and clinical characteristics. Rev. Med. Virol. 2014;24:90–102. doi: 10.1002/rmv.1776. - DOI - PMC - PubMed

Publication types