Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct 17;14(10):2284.
doi: 10.3390/v14102284.

Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants

José M Ruiz-Giardin  1   2 , Marta Rivilla  1 , Nieves Mesa  1 , Alejandro Morales  1 , Luis Rivas  1 , Aída Izquierdo  1 , Almudena Escribá  3 , Juan V San Martín  1   2 , David Bernal-Bello  1 , Elena Madroñal  1 , Ana I Farfán  1 , Marta Guerrero  1 , Ruth Calderón  1 , Miguel A Duarte  1 , Sara I Piedrabuena  1 , María Toledano-Macías  1 , José Á Satué  1 , Jorge Marrero  1 , Cristina L de Ancos  1 , Begoña Frutos  1 , Rafael Cristóbal  1 , Guillermo Soria  1 , Ibone Ayala-Larrañaga  1 , Lorena Carpintero  1 , Miguel de Hita  1 , Celia Lara  1 , Álvaro R Llerena  1 , Virginia García  1 , Raquel Jiménez  1 , Vanesa García  1 , Elena M Saiz-Lou  1 , Santiago Prieto  4 , Natalia González-Pereira  4 , Luis Antonio Lechuga  5 , Jorge Tarancón  5 , Sonia Gonzalo  1 ; FUENCOVID Group
Affiliations

Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants

José M Ruiz-Giardin et al. Viruses. .

Abstract

Objectives: This study aimed to compare the characteristics of fully and partially vaccinated or unvaccinated coronavirus disease 2019 (COVID-19) patients who were hospitalised in a population of 220,000 habitants.

Methods: Retrospective, observational, and population studies were conducted on patients who were hospitalised due to COVID-19 from March to October 2021. We assessed the impact of vaccination and other risk factors through Cox multivariate analysis.

Results: A total of 500 patients were hospitalised, among whom 77 (15.4%) were fully vaccinated, 86 (17.2%) were partially vaccinated, and 337 (67.4%) were unvaccinated. Fully vaccinated (FV) patients were older and had a higher Charlson index than those of partially vaccinated and unvaccinated patients (NFV). Bilateral pneumonia was more frequent among NFV (259/376 (68.9%)) than among FV patients (32/75 (42.7%)). The former had more intensive care unit admissions (63/423) than the latter (4/77); OR: 2.80; CI (1.07-9.47). Increasing age HZ: 1.1 (1.06-1.14)) and haematological disease at admission HZ: 2.99 (1.26-7.11)) were independent risk factors for higher mortality during the first 30 days of hospitalisation. The probability of an earlier discharge in the subgroup of 440 patients who did not die during the first 30 days of hospitalisation was related to age (older to younger: HZ: 0.98 (0.97-0.99)) and vaccination status.

Conclusions: Among the patients hospitalised because of COVID-19, complete vaccination was associated with less severe forms of COVID-19, with an earlier discharge date. Age and haematological disease were related to a higher mortality rate during the first 30 days of hospitalisation.

Keywords: COVID-19; ICU admission; SARS-CoV-2; death; hospital admission; vaccination.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
COVID-19 pandemic and hospital admissions in the area of Fuenlabrada.
Figure 2
Figure 2
Time to hospital discharge.
See this image and copyright information in PMC

References

    1. World Health Organization WHO Coronavirus (COVID-19) Dashboard. [(accessed on 12 July 2022)]. Available online: https://COVID19.who.int.
    1. Health Concierge, Community of Madrid COVID-19 Surveillance Epidemiological Report. [(accessed on 12 July 2022)]. Available online: https://www.comunidad.madrid/sites/default/files/doc/sanidad/epid/inform.... (In Spanish)
    1. Spanish Statistical Office. [(accessed on 12 July 2022)]. Available online: https://www.ine.es/jaxiT3/Tabla.htm?t=2881&L=0. (In Spanish)
    1. Fuenlabrada City Council Numerical Summary by Nationality. [(accessed on 20 November 2021)]. Available online: https://www.aytofuenlabrada.es/recursos/doc/SC/Estadisticas_y_territorio.... (In Spanish)
    1. Polack F.P., Thomas S.J., Kitchin N., Absalon J., Gurtman A., Lockhart S., Perez J.L., Marc G.P., Moreira E.D., Zerbini C., et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N. Engl. J. Med. 2020;383:2603–2615. doi: 10.1056/NEJMoa2034577. - DOI - PMC - PubMed