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Review
. 2022 Oct 10:9:1017965.
doi: 10.3389/fmed.2022.1017965. eCollection 2022.

Recent advances in the use of high flow nasal oxygen therapies

Kara D Wyatt  1 , Neha N Goel  2 , Jessica S Whittle  3   4
Affiliations
Review

Recent advances in the use of high flow nasal oxygen therapies

Kara D Wyatt et al. Front Med (Lausanne). .

Abstract

High flow nasal oxygen is a relatively new option for treating patients with respiratory failure, which decreases work of breathing, improves tidal volume, and modestly increases positive end expiratory pressure. Despite well-described physiologic benefits, the clinical impact of high flow nasal oxygen is still under investigation. In this article, we review the most recent findings on the clinical efficacy of high flow nasal oxygen in Type I, II, III, and IV respiratory failure within adult and pediatric patients. Additionally, we discuss studies across clinical settings, including emergency departments, intensive care units, outpatient, and procedural settings.

Keywords: high flow nasal cannula; high-flow oxygen; high-velocity therapy; non-invasive ventilation; respiratory distress; respiratory failure.

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Conflict of interest statement

Author JW is VP of Clinical Research for Vapotherm, Inc–a manufacturer of high flow oxygen systems. Author KW has been employed within the past 12 months as a scientific consultant. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Miller T, Saberi B, Saberi S. Computational fluid dynamics modeling of extrathoracic airway flush: evaluation of high flow nasal cannula design elements. J Pulm Respir Med. (2016) 6:376. 10.4172/2161-105X.1000376 - DOI
    1. Dysart K, Miller TL, Wolfson MR, Shaffer TH. Research in high flow therapy: mechanisms of action. Respir Med. (2009) 103:1400–5. 10.1016/j.rmed.2009.04.007 - DOI - PubMed
    1. Drake MG. High-flow nasal cannula oxygen in adults: an evidence-based assessment. Ann Am Thorac Soc. (2018) 15:145–55. 10.1513/AnnalsATS.201707-548FR - DOI - PubMed
    1. Lodeserto FJ, Lettich TM, Rezaie SR. High-flow nasal cannula: mechanisms of action and adult and pediatric indications. Cureus. (2018) 10:e3639. 10.7759/cureus.3639 - DOI - PMC - PubMed
    1. Nishimura M. High-flow nasal cannula oxygen therapy devices. Respir Care. (2019) 64:735–42. 10.4187/respcare.06718 - DOI - PubMed

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