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. 2023 Mar;47(3):512-525.
doi: 10.1111/aor.14436. Epub 2022 Nov 12.

A novel pulsatile blood pump design for cardiothoracic surgery: Proof-of-concept in a mock circulation

Elena Weber  1 , Albert Chong  2 , Andreas Liebold  1 , Markus Hoenicka  1
Affiliations

A novel pulsatile blood pump design for cardiothoracic surgery: Proof-of-concept in a mock circulation

Elena Weber et al. Artif Organs. 2023 Mar.

Abstract

Background: Pulsatile perfusion during extracorporeal circulation is a promising concept to improve perfusion of critical organs. Clinical benefits are limited by the amount of pulsatile energy provided by standard pumps. The present study investigated the properties of a novel positive displacement blood pump in a mock circulation.

Methods: The pump was attached to an aortic model with a human-like geometry and compliance as a pseudo patient. Hemodynamic data were recorded while the pump settings were adjusted systematically.

Results: Using a regular oxygenator, maximum flow was 2.6 L/min at a pressure of 27 mm Hg and a frequency (F) of 90 bpm. Pulse pressure (PP; 28.9 mm Hg) and surplus hemodynamic energy (SHE; 26.1% of mean arterial pressure) were highest at F = 40 bpm. Flow and pressure profiles appeared sinusoid. Using a low-resistance membrane ventilator to assess the impact of back pressure, maximum flow was 4.0 L/min at a pressure of 58.6 mm Hg and F = 40 bpm. At F = 40 bpm, PP was 58.7 mm Hg with an SHE of 33.4%. SHE decreased with increasing flow, heart rate, and systolic percentage but surpassed 10% with reasonable settings.

Conclusions: The present prototype achieved sufficient flow and pressure ranges only in the presence of a low-resistance membrane ventilator. It delivered supraphysiologic levels of pulse pressure and SHE. Further modifications are planned to establish this concept for adult pulsatile perfusion.

Keywords: blood pump; extracorporeal circulation; pulsatile perfusion; surplus hemodynamic energy.

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References

REFERENCES

    1. Anastasiadis K, Argiriadou H, Deliopoulos A, Antonitsis P. Minimal invasive extracorporeal circulation (MiECC): the state-of-the-art in perfusion. J Thorac Dis. 2019;11(Suppl 10):S1507-14.
    1. Wesolowski SA, Sauvage LR, Pinc RD. Extracorporeal circulation: the role of the pulse in maintenance of the systemic circulation during heart-lung by-pass. Surgery. 1955;37(4):663-82.
    1. Taylor KM. Pulsatile cardiopulmonary bypass. A review. J Cardiovasc Surg (Torino). 1981;22(6):561-8.
    1. Alghamdi AA, Latter DA. Pulsatile versus nonpulsatile cardiopulmonary bypass flow: an evidence-based approach. J Card Surg. 2006;21(4):347-54.
    1. Murphy GS, Hessel EA 2nd, Groom RC. Optimal perfusion during cardiopulmonary bypass: an evidence-based approach. Anesth Analg. 2009;108(5):1394-417.

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