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. 2022 Oct;54(3):285-291.
doi: 10.5152/eurasianjmed.2022.22213.

Clinical and Laboratory Findings by Serum Vitamin D Levels in Children with COVID-19

Ayse Ozden  1 , Hakan Doneray  2 , Emine Hafize Hafize Erdeniz  3 , Konca Altinkaynak  4 , Hakan Igan  5
Affiliations

Clinical and Laboratory Findings by Serum Vitamin D Levels in Children with COVID-19

Ayse Ozden et al. Eurasian J Med. 2022 Oct.

Abstract

Objective: The studies on children with COVID-19 are very limited. The aim of this study is to reveal the effect of serum 25-hydroxy vitamin D level on clinical and laboratory parameters.

Materials and methods: The study included 74 children (35 boys and 39 girls) diagnosed with COVID-19. The retrospective data were obtained from the file records of the patients. Seventy-four patients were divided into 3 groups (group 1, deficient; group 2, insufficient; and group 3, sufficient) according to their serum 25-hydroxy vitamin D levels.

Results: The mean age of all patients was 113.25 ± 64.55 months. The mean leucocyte count was substantially higher in group 3 compared to groups 1 and 2 (P = .05 and P = .002, respectively). The mean lymphocyte and platelet count in group 3 was remarkably higher than both groups 1 and 2 (P = .001 and P = .002; and P = .04 and P = .01, respectively). The mean serum parathyroid hormone concentration in group 1 was markedly higher than both groups 2 and 3 (P=.003 and P = .002, respectively) while the mean serum 25-hydroxy vitamin D level in group 1 was remarkably lower than both groups 2 and 3 (P=.001 and P=.001, respectively). Serum 25-hydroxy vitamin D concentrations were positively correlated with leucocyte, lymphocyte, and platelet counts (r=0.221, P=.05; r=0.396, P=.001; and r=0.249, P=.03, respectively) while there was a negative correlation with parathyroid hormone concentrations (r=-0,436, P=.001).

Conclusion: This study suggests that COVID-19 has a benign course in children and that serum 25-hydroxy vitamin D concentration may have a role in the lymphocyte count.

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Figures

Figure 1.
Figure 1.
Positive correlation between serum 25-hydroxy vitamin D level and lymphocyte count (r = 0.369, P = .001).
Figure 2.
Figure 2.
Positive correlation between serum 25-hydroxy vitamin D level and platelet count (r = 0.249, P = .03).
Figure 3.
Figure 3.
Negative correlation between serum 25-hydroxy vitamin D and parathyroid hormone levels (r = −0.436, P = .001).
Figure 4.
Figure 4.
Negative correlation between patients’ age and serum 25-hydroxy vitamin D level (r = −0.584, P = .001).
Figure 5.
Figure 5.
Negative correlation between patients’ age and lymphocyte count (r = −0.641, P = .001).
Figure 6.
Figure 6.
Negative correlation between patients’ age and platelet count (r = −0.470, P = .001).
See this image and copyright information in PMC

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