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. 2022 Oct;506(1):145-149.
doi: 10.1134/S001249662205012X. Epub 2022 Oct 27.

Maternal Methyl-Enriched Diet Increases Dopaminergic Tone of the Mesolimbic Brain System in Adult Offspring of WAG/Rij Rats

K Yu Sarkisova  1 , E A Fedosova  2 , A B Shatskova  2 , V B Narkevich  3 , V S Kudrin  3
Affiliations

Maternal Methyl-Enriched Diet Increases Dopaminergic Tone of the Mesolimbic Brain System in Adult Offspring of WAG/Rij Rats

K Yu Sarkisova et al. Dokl Biol Sci. 2022 Oct.

Abstract

The aim of this study is to find out whether maternal methyl-enriched diet affects the content of monoamines and their metabolites in brain structures of adult WAG/Rij offspring. It has been shown for the first time that maternal methyl-enriched diet (choline, betaine, folic acid, vitamin B12, L-methionine, zink) during the perinatal period increases dopaminergic tone of the mesolimbic brain system in adult offspring of WAG/Rij rats, which is accompanied by the suppression of the symptoms of genetic absence epilepsy and comorbid depression. Results suggest that maternal methyl-enriched diet during the perinatal period may be served as a new therapeutic strategy to prevent the development of a hypofunction of the mesolimbic dopaminergic brain system and associated genetic absence epilepsy and comorbid depression in offspring.

Keywords: absence epilepsy; brain monoamines; comorbid depression; genetic model; maternal methyl-enriched diet; offspring.

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