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Review
. 2023 Feb;48(2):340-361.
doi: 10.1007/s11064-022-03794-8. Epub 2022 Oct 27.

Rodent Models of Spinal Cord Injury: From Pathology to Application

Fuze Liu  1 , Yue Huang  1 , Hai Wang  2
Affiliations
Review

Rodent Models of Spinal Cord Injury: From Pathology to Application

Fuze Liu et al. Neurochem Res. 2023 Feb.

Abstract

Spinal cord injury (SCI) often has devastating consequences for the patient's physical, mental and occupational health. At present, there is no effective treatment for SCI, and appropriate animal models are very important for studying the pathological manifestations, injury mechanisms, and corresponding treatment. However, the pathological changes in each injury model are different, which creates difficulties in selecting appropriate models for different research purposes. In this article, we analyze various SCI models and introduce their pathological features, including inflammation, glial scar formation, axon regeneration, ischemia-reperfusion injury, and oxidative stress, and evaluate the advantages and disadvantages of each model, which is convenient for selecting suitable models for different injury mechanisms to study therapeutic methods.

Keywords: Axon regeneration; Glial scar; Inflammation; Pathology; Rodent model; Spinal cord injury.

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