Cell cycle associated miRNAs as target and therapeutics in lung cancer treatment

Abstract

Lung cancer is the primary cause of cancer related deaths worldwide. Limited therapeutic options and resistance to existing drugs are the major hindrances to the clinical success of this cancer. In the past decade, several studies showed the role of microRNA (miRNA) driven cell cycle regulation in lung cancer progression. Therefore, these small nucleotide molecules could be utilized as promising tools in lung cancer therapy. In this review, we highlighted the recent advancements in lung cancer therapy using cell cycle linked miRNAs. By highlighting the roles of the specific cell cycle core regulators affiliated miRNAs in lung cancer, we further outlined how these miRNAs can be explored in early diagnosis and treatment strategies to prevent lung cancer. With the provided information from our review, more medical efforts can ensure a potential breakthrough in miRNA-based lung cancer therapy.

Keywords: Biomarker; Cancer therapy; Cell cycle; NSCLC; miRNA.

Figure 1

Timeline of miRNAs in Lung Cancer Research.

Figure 2

The Role of miRNA in lung cancer formation.

Figure 3

(a) Therapeutic potentiality of miRNA in lung cancer treatment from target identification to treatment approach. (b) Diagrammatic representation of therapeutic mode of action of miRNAs within the cell structure during miRNA inhibition therapy and miRNA replacement therapy.