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. 2022 Oct 10;13(1):354-360.
doi: 10.1515/tnsci-2022-0252. eCollection 2022 Jan 1.

Correlation of serum RBP4 level with oxidative stress and unstable carotid plaque in patients with cerebral infarction

Qingqing Wang  1 , Sha Tian  1 , Dahai Xiao  1 , Ruotong Zhao  1 , Xiaoxuan Zhang  1 , Zhijie Dou  1 , Chengbo Li  1 , Zheng Ma  1
Affiliations

Correlation of serum RBP4 level with oxidative stress and unstable carotid plaque in patients with cerebral infarction

Qingqing Wang et al. Transl Neurosci. .

Abstract

Objectives: This study aimed to investigate the changes in serum levels of retinol-binding protein 4 (RBP4) with cerebral infarction, relationship of RBP4 with oxidative stress and carotid atherosclerosis, and its possible role in cerebral infarction.

Materials and methods: According to the results of cervical vascular ultrasound, the experimental group was divided into three groups: intima thickening group (n = 31), stable plaque group (n = 51), and unstable plaque group (n = 54). Forty healthy subjects were selected as the control group. Their serum levels of RBP4, 8-iso-prostaglandin-F2alpha (8-iso-PGF2α), and catalase (CAT) were measured. Carotid vascular ultrasound was used to measure the plaque area and intima-media thickness (IMT).

Results: The serum RBP4 and 8-iso-PGF2α levels, IMT and plaque area in the control, intimal thickening, stable plaque, and unstable plaque groups increased, while the serum level of CAT decreased (P < 0.001). The serum levels of RBP4 positively correlated with 8-iso-PGF2α, IMT, and plaque area and negatively correlated with CAT level. The area under the receiver operating characteristic curve was 0.778 in predicting unstable plaques.

Conclusions: The serum levels of RBP4 were significantly elevated in elderly patients with cerebral infarction and correlated with oxidative stress injury and the degree of atherosclerosis. Serum RBP4 has diagnostic value for unstable plaques in carotid arteries.

Keywords: carotid atherosclerosis; cerebral infarction; oxidative stress; retinol-binding protein 4.

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Conflict of interest statement

Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.

Figures

Figure 1
Figure 1
RBP4 concentrations in the study population.
Figure 2
Figure 2
CAT concentrations in the study population.
Figure 3
Figure 3
8-iso-PGF2α concentrations in the study population.
Figure 4
Figure 4
Correlation between the levels of RBP4 and CAT.
Figure 5
Figure 5
Correlation between the levels of RBP4 and 8-iso-PGF2α.
Figure 6
Figure 6
Correlation between RBP4 level and IMT.
Figure 7
Figure 7
Correlation between RBP4 level and plaque area.
Figure 8
Figure 8
ROC curve analysis of RBP4 (green line) and 8-iso-PGF2α (black line) as markers for diagnosing unstable carotid plaques.
See this image and copyright information in PMC

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