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Review
. 2022 Oct 28;10(5):995-1003.
doi: 10.14218/JCTH.2022.00086. Epub 2022 Apr 28.

Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review

Hozeifa Mohamed Hassan  1   2 , Jun Li  1   2
Affiliations
Review

Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review

Hozeifa Mohamed Hassan et al. J Clin Transl Hepatol. .

Abstract

Acute-on-chronic liver failure (ACLF) is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure. Establishing a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment strategies. In this context, this article provides a concise and inclusive review of breakthroughs in ACLF animal model development.

Keywords: Acute-on-chronic liver failure; Animal model; Hepatotoxicants; Inflammation; Liver failure.

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Conflict of interest statement

JL has been an editorial board member of Journal of Clinical and Translational Hepatology since 2019. HMH has no conflict of interests related to this publication.

Figures

Fig. 1
Fig. 1. Hepatotoxicant induction of liver failure.
(A) Mechanism of carbon tetrachloride (CCl4) induction of liver failure. The production of the trichloromethyl radical is the hallmark of oxidative damage. (B) Representative scheme of porcine serum (PS)-induced acute-on-chronic liver failure (ACLF), in which transcriptomic analysis of liver tissues reveals immune-metabolism disorder as the core axis in ACLF pathogenesis.
See this image and copyright information in PMC

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