Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct 28;10(5):995-1003.
doi: 10.14218/JCTH.2022.00086. Epub 2022 Apr 28.

Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review

Hozeifa Mohamed Hassan  1   2 , Jun Li  1   2
Affiliations
Review

Prospect of Animal Models for Acute-on-chronic Liver Failure: A Mini-review

Hozeifa Mohamed Hassan et al. J Clin Transl Hepatol. .

Abstract

Acute-on-chronic liver failure (ACLF) is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure. Establishing a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment strategies. In this context, this article provides a concise and inclusive review of breakthroughs in ACLF animal model development.

Keywords: Acute-on-chronic liver failure; Animal model; Hepatotoxicants; Inflammation; Liver failure.

PubMed Disclaimer

Conflict of interest statement

JL has been an editorial board member of Journal of Clinical and Translational Hepatology since 2019. HMH has no conflict of interests related to this publication.

Figures

Fig. 1
Fig. 1. Hepatotoxicant induction of liver failure.
(A) Mechanism of carbon tetrachloride (CCl4) induction of liver failure. The production of the trichloromethyl radical is the hallmark of oxidative damage. (B) Representative scheme of porcine serum (PS)-induced acute-on-chronic liver failure (ACLF), in which transcriptomic analysis of liver tissues reveals immune-metabolism disorder as the core axis in ACLF pathogenesis.
See this image and copyright information in PMC

References

    1. Qin L, Crawford JM. Zakim and Boyer’s hepatology: A textbook of liver disease. 7th edition. Elsevier, Inc.; 2018.
    1. Vaja R, Rana M. Drugs and the liver. Anaesth Intensive Care Med. 2020;21(10):517–523. doi: 10.1016/j.mpaic.2020.07.001. - DOI
    1. Trefts E, Gannon M, Wasserman DH. The liver. Curr Biol. 2017;27(21):R1147–R1151. doi: 10.1016/j.cub.2017.09.019. - DOI - PMC - PubMed
    1. Gordillo M, Evans T, Gouon-Evans V. Orchestrating liver development. Development. 2015;142(12):2094–2108. doi: 10.1242/dev.114215. - DOI - PMC - PubMed
    1. Guillot A, Tacke F. Liver Macrophages: Old Dogmas and New Insights. Hepatol Commun. 2019;3(6):730–743. doi: 10.1002/hep4.1356. - DOI - PMC - PubMed