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Case Reports
. 2022 Jul 6;35(6):840-842.
doi: 10.1080/08998280.2022.2093589. eCollection 2022.

Combined acute myeloid leukemia and panhypopituitarism

Busara Songtanin  1 , Tsuzumi Kanaoka  2 , Joan Chandra  3 , Sushela Chaidarun  3   4
Affiliations
Case Reports

Combined acute myeloid leukemia and panhypopituitarism

Busara Songtanin et al. Proc (Bayl Univ Med Cent). .

Abstract

Panhypopituitarism is an extremely rare disorder in acute myeloid leukemia (AML). To our knowledge, only six cases have been reported. Of note, central diabetes insipidus is known to be associated with AML in patients with certain cytogenic abnormalities, such as monosomy chromosome 7 and inv(3)(q21;q26). We describe a 30-year-old incarcerated woman with newly diagnosed AML who developed panhypopituitarism. Her cytogenetic studies revealed a normal karyotype, were negative for inv(3)(q21;q26), but were positive for FMS-like tyrosine kinase 3 internal tandem duplication.

Keywords: Acute myeloid leukemia; diabetes insipidus; panhypopituitarism.

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Figures

Figure 1.
Figure 1.
Brain MRI showing heterogeneous thickening of the infundibulum and an absence of the posterior pituitary T1 bright spot (arrows), which can be seen in central diabetes insipidus. This imaging suggests leukemic infiltration of the pituitary stalk and posterior pituitary.
See this image and copyright information in PMC

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