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Review
. 2022 Nov;28(6):889-905.
doi: 10.1111/srt.13211. Epub 2022 Oct 28.

Role of skin autofluorescence in managing renal and cardiac diseases in outpatient dermatology

Farshid Etaee  1 , Tarek Naguib  2 , Mohamad Goldust  3 , Steven Daveluy  4 , Howard Maibach  5
Affiliations
Review

Role of skin autofluorescence in managing renal and cardiac diseases in outpatient dermatology

Farshid Etaee et al. Skin Res Technol. 2022 Nov.

Abstract

Introduction: The accumulation of tissue-advanced glycation end products in skin results from complex and consecutive reactions and can be measured by skin autofluorescence (SAF) reader devices. This overview discusses studies evaluating the utilization of SAF in screening renal and cardiac disease.

Materials and methods: Literature search was performed using Google Scholar, PubMed, Springer, Ovid, and ScienceDirect.

Results: SAF was an independent predictor of progression of chronic kidney disease (CKD) and was elevated in subjects on hemodialysis and peritoneal dialysis. Furthermore, SAF was significantly associated with cardiovascular events, cardiovascular mortality, and all-cause mortality in CKD patients. Other studies revealed a correlation between SAF and arterial stiffness, vascular damage, and subclinical atherosclerosis. A vegetarian diet was associated with lower SAF levels, whereas malnutrition was correlated with higher levels and increased mortality.

Conclusions: SAF measurement may be useful in managing renal and cardiac disease. Future studies are needed to clarify the specific role of SAF in the management of CKD and its noninvasive office utilization to identify comorbidities in inflammatory diseases, such as psoriasis.

Keywords: advanced glycation end products (AGE); end-stage renal disease; kidney disease; kidney failure; skin autofluorescence (SAF).

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Conflict of interest statement

The authors declare that they have no conflicts of interest to disclose.

References

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