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. 2023 Feb;88(2):129-133.
doi: 10.1111/cod.14240. Epub 2022 Nov 22.

Contact allergy to hydroxyisohexyl 3-cyclohexene carboxaldehyde in Italy: Prevalence, trend, and concordance with fragrance mix II

Luca Stingeni  1 , Katharina Hansel  1 , Monica Corazza  2 , Caterina Foti  3 , Donatella Schena  4 , Gabriella Fabbrocini  5 , Cataldo Patruno  6 , Leonardo Bianchi  1 , Marta Tramontana  1 , Fabrizio Guarneri  7 ; SIDAPA Study Group
Affiliations

Contact allergy to hydroxyisohexyl 3-cyclohexene carboxaldehyde in Italy: Prevalence, trend, and concordance with fragrance mix II

Luca Stingeni et al. Contact Dermatitis. 2023 Feb.

Abstract

Background: Hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC), contained in fragrance mix II (FM II), has been recognized as a contact sensitizer since the mid-1990s. After several attempts to reduce its use during the last two decades, HICC was permanently banned from the European market in August 2021.

Objectives: To assess the prevalence and the time trend of contact allergy to HICC and to investigate the concordance of HICC allergy compared to FM II allergy in an unselected Italian patch test population.

Methods/patients: Retrospective analysis on demographics and patch test results of HICC-sensitized and/or FM II-sensitized patients was performed over a 6-year period (2016-2021) at 6 patch test Clinics in Italy.

Results: Among 7266 patients (4942 females, 68.0%, mean age 45.4 ± 20.6 years), 1% (70) resulted positive to HICC and 2.1% (153) to FM II. Clinical relevance was documented in 72.9% (51/70) of HICC positive patients. Among the 169 HICC and/or FM II positive patients, 9.5% had a positive reaction to HICC only, 31.9% to both HICC and FM II, and 58.6% to FM II only. The prevalence trend line of HICC positive reactions showed a decrease from 1.15% (2016) to 0.96% (2021).

Conclusions: We documented a decreasing trend of HICC allergy in Italy, in line with the data recently reported in literature. Nevertheless, HICC should be maintained in the baseline series to monitor the benefits of its ban from the European market.

Keywords: fragrance mix II; hydroxyisohexyl 3-cyclohexene carboxaldehyde; patch test; prevalence; time trend.

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References

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