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Published Erratum
. 2022 Nov 7;219(11):e2022065010252022c.
doi: 10.1084/jem.2022065010252022c. Epub 2022 Oct 28.

Correction: Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis

Tilman Schneider-Hohendorf, Lisa Ann Gerdes, Béatrice Pignolet, Rachel Gittelman, Patrick Ostkamp, Florian Rubelt, Catarina Raposo, Björn Tackenberg, Marianne Riepenhausen, Claudia Janoschka, Christian Wünsch, Florence Bucciarelli, Andrea Flierl-Hecht, Eduardo Beltrán, Tania Kümpfel, Katja Anslinger, Catharina C Gross, Heidi Chapman, Ian Kaplan, David Brassat, Hartmut Wekerle, Martin Kerschensteiner, Luisa Klotz, Jan D Lünemann, Reinhard Hohlfeld, Roland Liblau, Heinz Wiendl, Nicholas Schwab
Published Erratum

Correction: Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis

Tilman Schneider-Hohendorf et al. J Exp Med. .
No abstract available

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Figures

Figure S3.
Figure S3.
Quantification of pathogen-specific TCRβ sequences in TCRβ repertoires with regard to MS treatments. (A–C) SARS-CoV-2 (A), CMV (B), and influenza A (C). TCRβ sequence matches quantified in untreated MS patients (red dots and line) and anti-VLA-4–treated MS patients (orange dots and line) against sequencing depth (number of productive templates in the sample; SARS-CoV-2:qanti-VLA-4 = 0.41808; CMV:qanti-VLA-4 = 1; influenza A:qanti-VLA-4 = 1; nMS = 248; nanti-VLA-4 = 73); lines indicate linear regressions; q values indicate adjusted significance of treatment in linear models with the covariates sequencing depth, age, sex, and HLA. (D) EBV TCRβ sequence matches quantified in treatment-naive MS patients (red dots) and MS patients only treated with IFNβ (cyan dots; qIFNbeta = 1; nMS = 29; nIFNbeta = 123); q values indicate adjusted significance of treatment in linear models with the covariates sequencing depth, age, sex, and HLA. (E) EBV TCRβ sequence matches quantified in MS patients before their anti-CD20 treatment (red dots), and after their anti-CD20 treatment (yellow dots; qanti-CD20 = 0.068; nMS = 14; nanti-CD20 = 14). Colored lines indicate standard error of the mean of the sequencing pools for the respective sample; gray lines connect samples from the same individual. q values indicate adjusted significance of anti-CD20 treatment in linear mixed models with the covariates sequencing depth, age, sex, treatment, and sequencing pools nested within samples within individuals.
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Erratum for

  • Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis.
    Schneider-Hohendorf T, Gerdes LA, Pignolet B, Gittelman R, Ostkamp P, Rubelt F, Raposo C, Tackenberg B, Riepenhausen M, Janoschka C, Wünsch C, Bucciarelli F, Flierl-Hecht A, Beltrán E, Kümpfel T, Anslinger K, Gross CC, Chapman H, Kaplan I, Brassat D, Wekerle H, Kerschensteiner M, Klotz L, Lünemann JD, Hohlfeld R, Liblau R, Wiendl H, Schwab N. Schneider-Hohendorf T, et al. J Exp Med. 2022 Nov 7;219(11):e20220650. doi: 10.1084/jem.20220650. Epub 2022 Sep 1. J Exp Med. 2022. PMID: 36048016 Free PMC article.

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