The MATRICS Consensus Cognitive Battery: An Update

Keith H Nuechterlein^{1

2}, Michael F Green^{3

4}, Robert S Kern^{3

4}

Affiliations

¹ Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. keithn@ucla.edu.
² Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. keithn@ucla.edu.
³ Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
⁴ VISN 22 Mental Illness Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

PMID: 36306054
DOI: 10.1007/7854_2022_395

The MATRICS Consensus Cognitive Battery: An Update

Keith H Nuechterlein et al. Curr Top Behav Neurosci. 2023.

. 2023:63:1-18.

doi: 10.1007/7854_2022_395.

Authors

Keith H Nuechterlein^{1

2}, Michael F Green^{3

4}, Robert S Kern^{3

4}

Affiliations

¹ Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. keithn@ucla.edu.
² Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. keithn@ucla.edu.
³ Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
⁴ VISN 22 Mental Illness Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

PMID: 36306054
DOI: 10.1007/7854_2022_395

Abstract

Through a series of NIMH-supported consensus-building meetings of experts and empirical comparisons of candidate tests, the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative developed a battery of standardized cognitive measures to allow reliable evaluation of results from clinical trials of promising interventions for core cognitive deficits in this disorder. Ten tests in seven cognitive domains were selected for the MATRICS Consensus Cognitive Battery (MCCB). The MCCB has now been translated into 39 languages/dialects and has been employed in more than 145 clinical trials. It has become the standard cognitive change measure for studies of both pharmacological and training-based interventions seeking to improve cognitive deficits in schizophrenia. We summarize its applications and its relationship to the subsequent development of the NIMH RDoC Matrix.

Keywords: Clinical trials; Cognition; International; MATRICS; Schizophrenia.

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The MATRICS Consensus Cognitive Battery: An Update

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The MATRICS Consensus Cognitive Battery: An Update

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