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. 1978 Sep;53(9):737-9.
doi: 10.1136/adc.53.9.737.

Neonatal tetanus treated with high dosage diazepam

B H Khoo, E L Lee, K L Lam

Neonatal tetanus treated with high dosage diazepam

B H Khoo et al. Arch Dis Child. 1978 Sep.

Abstract

The combination of continuous intravenous infusion of diazepam (20--40 mg/kg per day) and intragastric phenobarbitone (10--15 mg/kg per day in 4 divided doses) was used to treat 19 cases of neonatal tetanus. Mortality was 2/19 (11%). This regimen was considered to have reduced the mortality and the need for artificial ventilation. The main side effects encountered were severe drowsiness, coma, and apnoeic episodes which were reversible when the level of diazepam was reduced.

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