Microglia are SYK of Aβ and cell debris

Dorothy P Schafer¹, Jacob M Stillman²

Affiliations

¹ Department of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: dorothy.schafer@umassmed.edu.
² Department of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA; University of Massachusetts Chan Morningside Graduate School of Biomedical Sciences, Neuroscience Program, Worcester, MA, USA.

PMID: 36306731
DOI: 10.1016/j.cell.2022.09.043

Comment

Microglia are SYK of Aβ and cell debris

Dorothy P Schafer et al. Cell. 2022.

. 2022 Oct 27;185(22):4043-4045.

doi: 10.1016/j.cell.2022.09.043.

Authors

Dorothy P Schafer¹, Jacob M Stillman²

Affiliations

¹ Department of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: dorothy.schafer@umassmed.edu.
² Department of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA; University of Massachusetts Chan Morningside Graduate School of Biomedical Sciences, Neuroscience Program, Worcester, MA, USA.

PMID: 36306731
DOI: 10.1016/j.cell.2022.09.043

Abstract

During neurodegenerative disease, resident CNS macrophages termed "microglia" assume a neuroprotective role and engulf toxic protein aggregates and cell debris. In this issue of Cell, two groups independently show how spleen tyrosine kinase (SYK) acts downstream of microglial surface receptors to propagate this neuroprotective program in vivo.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests Dr. Dorothy Schafer is a consultant for Neurocrine Biosciences.

Comment on

SYK coordinates neuroprotective microglial responses in neurodegenerative disease.
Ennerfelt H, Frost EL, Shapiro DA, Holliday C, Zengeler KE, Voithofer G, Bolte AC, Lammert CR, Kulas JA, Ulland TK, Lukens JR. Ennerfelt H, et al. Cell. 2022 Oct 27;185(22):4135-4152.e22. doi: 10.1016/j.cell.2022.09.030. Epub 2022 Oct 17. Cell. 2022. PMID: 36257314 Free PMC article.
TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways.
Wang S, Sudan R, Peng V, Zhou Y, Du S, Yuede CM, Lei T, Hou J, Cai Z, Cella M, Nguyen K, Poliani PL, Beatty WL, Chen Y, Cao S, Lin K, Rodrigues C, Ellebedy AH, Gilfillan S, Brown GD, Holtzman DM, Brioschi S, Colonna M. Wang S, et al. Cell. 2022 Oct 27;185(22):4153-4169.e19. doi: 10.1016/j.cell.2022.09.033. Cell. 2022. PMID: 36306735 Free PMC article.

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Microglia are SYK of Aβ and cell debris

Affiliations

Microglia are SYK of Aβ and cell debris

Authors

Affiliations

Abstract

Conflict of interest statement

Comment on

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Medical