Adding data to gut feelings
- PMID: 36306732
- DOI: 10.1016/j.cell.2022.10.002
Adding data to gut feelings
Abstract
Pain-sensing neurons detect environmental insults and tissue injury, driving avoidance behavior and the local release of neuropeptides. Two related papers in this issue of Cell report that gut-innervating pain neurons sense bacterial presence to both shape the constituents of the gut microbiome and protect against excessive inflammation.
Crown Copyright © 2022. Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection.Cell. 2022 Oct 27;185(22):4170-4189.e20. doi: 10.1016/j.cell.2022.09.008. Epub 2022 Oct 14. Cell. 2022. PMID: 36240781 Free PMC article.
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Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.Cell. 2022 Oct 27;185(22):4190-4205.e25. doi: 10.1016/j.cell.2022.09.024. Epub 2022 Oct 14. Cell. 2022. PMID: 36243004 Free PMC article.
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