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. 2022 Oct 28;62(1):38.
doi: 10.1186/s42358-022-00270-3.

Maintained activity in ankylosing spondylitis patients treated with TNFi and/or NSAID for at least 12 weeks: a cross-sectional study in Brazil

Ricardo Acayaba de Toledo  1 , Felipe Merchan Ferraz Grizzo  2 , Vander Fernandes  3 , Renato Calheiros  4 , Ricardo T Russo  5 , Gustavo Rosal  5 , Luiz Roberto Delboni Marchese  5 , Roberto Tunala  5 , Renato Watanabe  6 , Marina Gabriela Birck  6 , Guilherme Silva Julian  6 , Francisco Jose Forestiero  7
Affiliations

Maintained activity in ankylosing spondylitis patients treated with TNFi and/or NSAID for at least 12 weeks: a cross-sectional study in Brazil

Ricardo Acayaba de Toledo et al. Adv Rheumatol. .

Abstract

Background: The aim of this study was to evaluate disease activity among patients with axial spondyloarthritis (AS) treated with tumor necrosis factor inhibitors (TNFi) and/or nonsteroidal anti-inflammatory drugs (NSAIDs) for at least 12 weeks in private outpatient settings in Brazil.

Methods: This was a cross-sectional, real-world study conducted in 17 Brazilian private health care institutes. Patients were selected if diagnosed with AS or axial radiographic spondyloarthritis (AxSpA) and treated with NSAIDs or TNFi for at least 12 weeks within the last 26 weeks prior to enrollment. The data were collected from interviewed-based and self-administered questionnaires from patients and physicians. Disease activity was defined as active (≥ 4), low /suboptimal (≥ 2 and < 4) and inactive (< 4) by Bath AS Disease Activity Index (BASDAI) and/or very high (≥ 3.5), high (≥ 2.1 to < 3.5), low (≥ 1.3 to < 2.1), and inactive (< 1.3) by AS Disease Activity Score (ASDAS-CRP). Both patients and physicians' perceptions of disease control were assessed using a numeric rating scale (NRS; 0-inactive to 10-very active disease).

Results: The cohort included 378 patients with a mean age of 46 years, and the median time since diagnosis until enrollment was 5.4 years (interquartile range 2.7-10.5). Most patients were treated with TNFi alone (74%), followed by TNFi in combination with NSAID (15%), and NSAID alone (11%). About half AS patients showed active disease and 24% of patients showed low activity/suboptimal disease control despite having been treated for at least 12 weeks. Although TNFi showed better disease control than NSAID, inactive disease was experienced by few patients. The NRS (mean [standard deviation]) score for disease perception was 4.24 (3.3) and 2.85 (2.6) for patients and physicians, respectively.

Conclusion: This real-world study showed that most AS patients on TNFi and/or NSAID had not achieved an adequate disease control, as almost 75% of them exhibited active disease or low activity/suboptimal disease control. There remains a need for improved disease management among patients with AS.

Keywords: Ankylosing spondylitis; Axial radiographic spondyloarthritis; Disease activity; Nonsteroidal anti-inflammatory drug; Patient-reported outcome; Real-world study; Tumor necrosis factor inhibitors.

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Conflict of interest statement

Francisco Jose Forestiero, Ricardo T. Russo, Renato Calheiros, Roberto Tunala, and Gustavo Rosal are employed by Novartis Biociências. Marina Gabriela Birck, Guilherme Silva Julian, and Renato Watanabe de Oliveira are employed by IQVIA.

Figures

Fig. 1
Fig. 1
Disease activity according to (A) BASDAI and (B) ASDAS-CRP, as the number and percentage of patients defined as inactive (blue), low disease activity (yellow), active or high activity (orange), and very high activity [ASDAS-CRP only] (dark orange)
Fig. 2
Fig. 2
AUC of patient’s (A, B) and physician’s (C, D) NRS for predicting disease activity according to BASDAI and ASDAS-CRP ASDAS-CRP Ankylosing Spondylitis Disease Activity Score, AUC area under the curve, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, CI confidence interval, NRS numeric rating scale
See this image and copyright information in PMC

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