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Editorial
. 2023 May;290(9):2208-2213.
doi: 10.1111/febs.16646. Epub 2022 Oct 29.

In conversation with Peter Macheroux

Eleni Skourti  1 , Peter Macheroux  2
Affiliations
Free article
Editorial

In conversation with Peter Macheroux

Eleni Skourti et al. FEBS J. 2023 May.
Free article

Abstract

Peter Macheroux is Professor of Biochemistry and Head of the Institute of Biochemistry at Graz University of Technology in Austria. Peter's research spans a diverse selection of topics, and his work has contributed significantly towards advancing our understanding of bacterial enzymology, plant physiology and the molecular pathways that underlie human pathophysiology. Among Peter's many scientific achievements, he has led the team that recognised DPP3 as a biomarker for cardiovascular diseases, with the subsequent therapeutic implications of the development of DPP3 inhibitors. In this interview-based article, Peter provides an overview of his research focus and goals, recalls some of his great scientific breakthroughs and describes what the key current challenges in his research field are.

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References

Key publications

    1. Winkler A, Lyskowski A, Riedl S, Puhl M, Kutchan T, Macheroux P, et al. A concerted mechanism for berberine bridge enzyme. Nat Chem Biol. 2008;4:739-41.
    1. Rodrigues-Vendramini FAV, Marschalk C, Toplak M, Macheroux P, de Souza Bonfim-Mendonca P, Svidzinski TIE, et al. Promising new antifungal treatment targeting chorismate synthase from Paracoccidioides brasiliensis. Antimicrob Agents Chemother. 2019;63:e01097-18. https://doi.org/10.1128/AAC.01097-18
    1. Bueno PSA, Rodrigues-Vendramini FAV, Toplak M, Macheroux P, Kioshima Cotica ES, Seixas FAV. New inhibitors of chorismate synthase present antifungal activity against Paracoccidioides brasiliensis. Future Microbiol. 2019;14:969-80. https://doi.org/10.2217/fmb-2019-0052
    1. Hall M, Stueckler C, Kroutil W, Macheroux P, Faber K. Asymmetric bioreduction of activated alkenes using cloned 12-oxophytodienoate reductase isoenzymes OPR-1 and OPR-3 from Lycopersicon esculentum (tomato): a striking switch of stereopreference. Angew Chem Int Ed Engl. 2007;46:3934-7.
    1. Schrittwieser JH, Resch V, Sattler J, Lienhart W-D, Durchschein K, Winkler A, et al. Biocatalytic enantioselective oxidative C-C coupling by aerobic C-H activation of N-CH3 to yield novel berberine alkaloid derivatives. Angew Chem Int Ed Engl. 2011;50:1068-71.

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