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Review
. 2022 Oct;82(7-8):625-638.
doi: 10.1002/dneu.22905. Epub 2022 Nov 15.

Microglia in motor neuron disease: Signaling evidence from last 10 years

Min-Jia Wang  1 , Lu Kang  1 , Yao-Zheng Wang  1 , Bi-Ru Yang  2 , Chun Zhang  1 , Yu-Feng Lu  1 , Liang Kang  3
Affiliations
Review

Microglia in motor neuron disease: Signaling evidence from last 10 years

Min-Jia Wang et al. Dev Neurobiol. 2022 Oct.

Abstract

Motor neuron disease (MND), including amyotrophic lateral sclerosis, spinal muscular atrophy and others, involved the upper or lower motor neurons selective loss, is characterized by neurodegeneration and neuroinflammation, in conjunction with microglia. We summarized that pathways and key mediators are associated with microglia, such as fractalkine signaling, purinergic signaling, NF-κB signaling, p38 MAPK signaling, TREM2-APOE signaling, ROCK signaling, C1q signaling, and Ion channel, which are involved in the activation, proliferation, and inflammation of microglia. This review aims to identify the microglia-related molecular target and explore potential treatment strategies for MND based on that target.

Keywords: ALS; MND; microglia; neuroinflammation; signaling.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
The signaling and relevant mediators involved in motor neuron disease (MND) related to microglia
See this image and copyright information in PMC

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