Weekly Rapid Antigen Test Screening for COVID-19 in Patients on Hemodialysis

doi:10.21873/invivo.13020

. 2022 Nov-Dec;36(6):2823-2827.

doi: 10.21873/invivo.13020.

Weekly Rapid Antigen Test Screening for COVID-19 in Patients on Hemodialysis

Gaetano Alfano¹, Roberta Scarmignan², Alessio Amurri², Francesco Fontana³, Silvia Giovanella^{2

4}, Giulia Ligabue², William Gennari⁵, Monica Pecorari⁵, Mario Sarti⁶, Giovanni Guaraldi⁷, Gianni Cappelli², Mariacristina Gregorini⁸, Riccardo Magistroni^{3

2}, Gabriele Donati^{3

2}

Affiliations

¹ Nephrology, Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy; gaetano.alfano@unimore.it.
² Surgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy.
³ Nephrology, Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy.
⁴ Clinical and Experimental Medicine Ph.D. Program, University of Modena and Reggio Emilia, Modena, Italy.
⁵ Virology and Molecular Microbiology Unit, University Hospital of Modena, Modena, Italy.
⁶ Clinical Microbiology Unit, University Hospital of Modena, Modena, Italy.
⁷ Clinic of Infectious Diseases, University Hospital of Modena, Modena, Italy.
⁸ Nephrology and Dialysis, AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy.

PMID: 36309377
PMCID: PMC9677751
DOI: 10.21873/invivo.13020

Weekly Rapid Antigen Test Screening for COVID-19 in Patients on Hemodialysis

Gaetano Alfano et al. In Vivo. 2022 Nov-Dec.

. 2022 Nov-Dec;36(6):2823-2827.

doi: 10.21873/invivo.13020.

Authors

Affiliations

¹ Nephrology, Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy; gaetano.alfano@unimore.it.
² Surgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy.
³ Nephrology, Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy.
⁴ Clinical and Experimental Medicine Ph.D. Program, University of Modena and Reggio Emilia, Modena, Italy.
⁵ Virology and Molecular Microbiology Unit, University Hospital of Modena, Modena, Italy.
⁶ Clinical Microbiology Unit, University Hospital of Modena, Modena, Italy.
⁷ Clinic of Infectious Diseases, University Hospital of Modena, Modena, Italy.
⁸ Nephrology and Dialysis, AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy.

PMID: 36309377
PMCID: PMC9677751
DOI: 10.21873/invivo.13020

Abstract

Background/aim: COVID-19 is a concerning issue among in-center hemodialysis (HD) patients. To prevent COVID-19 diffusion in our HD facility, weekly rapid nasal antigen test screening was performed for all asymptomatic patients on chronic HD. This study aimed to assess the performance of weekly rapid antigen test in detecting SARS-CoV-2 infection among asymptomatic patients receiving HD.

Patients and methods: A retrospective analysis was conducted in HD patients who underwent rapid antigen test screening from December 2021 to March 2022. The diagnosis of COVID-19 with rapid antigen test was always confirmed by reverse transcriptase-polymerase chain reaction (RT-PCR).

Results: During the observational period, 1,748 rapid antigen tests were performed in 220 HD patients. Mean age was 68.4±14.6 years. Fifteen (8.5%) patients resulted positive for SARS-CoV-2 infection using rapid antigen tests. The diagnosis was subsequently confirmed in 14 (93.3%) patients by RT-PCR. During the same period, 12 (5.4%) symptomatic patients, regularly screened with weekly rapid antigen test, resulted positive for SARS-CoV-2 infection using RT-PCR. Overall, weekly rapid antigen test screening identified 14 out of 26 (53.8%) COVID-19 cases and showed a positive predictive value of 93%.

Conclusion: Weekly antigen test screening of asymptomatic patients on chronic HD detected around half of the COVID-19 cases in our population.

Keywords: COVID-19; COVID-19 testing; PCR; Rapid antigen test; SARS-CoV-2; coronavirus; dialysis; hemodialysis; polymerase chain reaction; screening.

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Conflict of interest statement

The Authors have no conflicts of interest to declare in relation to this study.

Figures

**Figure 1. Flowchart of rapid antigen test screening in patients on in-center hemodialysis.**

See this image and copyright information in PMC

Cited by

COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review.
McDonnell T, Wu HHL, Kalra PA, Chinnadurai R. McDonnell T, et al. Biomedicines. 2023 Mar 16;11(3):926. doi: 10.3390/biomedicines11030926. Biomedicines. 2023. PMID: 36979905 Free PMC article. Review.

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[1] Tiruneh SA, Tesema ZT, Azanaw MM, Angaw DA. The effect of age on the incidence of COVID-19 complications: a systematic review and meta-analysis. Syst Rev. 2021;10(1):80. doi: 10.1186/s13643-021-01636-2. - DOI - PMC - PubMed

[2] Tiruneh SA, Tesema ZT, Azanaw MM, Angaw DA. The effect of age on the incidence of COVID-19 complications: a systematic review and meta-analysis. Syst Rev. 2021;10(1):80. doi: 10.1186/s13643-021-01636-2. - DOI - PMC - PubMed

[3] Ortega E, Corcoy R, Gratacòs M, Cos Claramunt FX, Mata-Cases M, Puig-Treserra R, Real J, Vlacho B, Castelblanco E, Domingo P, Khunti K, Franch-Nadal J, Mauricio D. Risk factors for severe outcomes in people with diabetes hospitalised for COVID-19: a cross-sectional database study. BMJ Open. 2021;11(7):e051237. doi: 10.1136/bmjopen-2021-051237. - DOI - PMC - PubMed

[4] Ortega E, Corcoy R, Gratacòs M, Cos Claramunt FX, Mata-Cases M, Puig-Treserra R, Real J, Vlacho B, Castelblanco E, Domingo P, Khunti K, Franch-Nadal J, Mauricio D. Risk factors for severe outcomes in people with diabetes hospitalised for COVID-19: a cross-sectional database study. BMJ Open. 2021;11(7):e051237. doi: 10.1136/bmjopen-2021-051237. - DOI - PMC - PubMed

[5] Cianciolo G, Donati G, La Manna G, Ferri A, Cuna V, Ubaldi G, Corsini S, Lanci N, Colì L, Stefoni S. The cardiovascular burden of end-stage renal disease patients. Minerva Urol Nefrol. 2010;62(1):51–66. - PubMed

[6] Cianciolo G, Donati G, La Manna G, Ferri A, Cuna V, Ubaldi G, Corsini S, Lanci N, Colì L, Stefoni S. The cardiovascular burden of end-stage renal disease patients. Minerva Urol Nefrol. 2010;62(1):51–66. - PubMed

[7] Nordio M, Reboldi G, Di Napoli A, Quintaliani G, Alberici F, Postorino M, Aucella F, Messa P, Brunori G, Italian Society of Nephrology COVID-19 Research Group Risk factors and action thresholds for the novel coronavirus pandemic. Insights from the Italian Society of Nephrology COVID-19 Survey. J Nephrol. 2021;34(2):325–335. doi: 10.1007/s40620-020-00946-3. - DOI - PMC - PubMed

[8] Nordio M, Reboldi G, Di Napoli A, Quintaliani G, Alberici F, Postorino M, Aucella F, Messa P, Brunori G, Italian Society of Nephrology COVID-19 Research Group Risk factors and action thresholds for the novel coronavirus pandemic. Insights from the Italian Society of Nephrology COVID-19 Survey. J Nephrol. 2021;34(2):325–335. doi: 10.1007/s40620-020-00946-3. - DOI - PMC - PubMed

[9] Alfano G, Ferrari A, Magistroni R, Fontana F, Cappelli G, Basile C. The frail world of haemodialysis patients in the COVID-19 pandemic era: a systematic scoping review. J Nephrol. 2021;34(5):1387–1403. doi: 10.1007/s40620-021-01136-5. - DOI - PMC - PubMed

[10] Alfano G, Ferrari A, Magistroni R, Fontana F, Cappelli G, Basile C. The frail world of haemodialysis patients in the COVID-19 pandemic era: a systematic scoping review. J Nephrol. 2021;34(5):1387–1403. doi: 10.1007/s40620-021-01136-5. - DOI - PMC - PubMed

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Weekly Rapid Antigen Test Screening for COVID-19 in Patients on Hemodialysis

Affiliations

Weekly Rapid Antigen Test Screening for COVID-19 in Patients on Hemodialysis

Authors

Affiliations

Abstract

Conflict of interest statement

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References

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