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. 2023 Jun;38(3):648-656.
doi: 10.1002/ncp.10929. Epub 2022 Oct 29.

Long-term follow-up for pediatric intestinal pseudo-obstruction patients in China

Powei Tang  1 , Lina Lu  1 , Weihui Yan  1   2 , Yijng Tao  1 , Haixia Feng  1 , Wei Cai  1   2   3   4 , Ying Wang  1   2
Affiliations

Long-term follow-up for pediatric intestinal pseudo-obstruction patients in China

Powei Tang et al. Nutr Clin Pract. 2023 Jun.

Abstract

Background: Pediatric intestinal pseudo-obstruction (PIPO) is a heterogeneous and severe group of disorders with a high mortality rate. Patients with PIPO often develop malnutrition and need long-term nutrition support. This study aimed to determine the nutrition status, particularly micronutrients, during the long-term follow-up of patients with PIPO.

Methods: Fifty-eight patients with PIPO were followed up for at least 6 months between January 2008 and December 2020 in our hospital. PIPO was diagnosed based on the European society for pediatric gastroenterology, hepatology, and nutrition consensus. Data on clinical characteristics, medical and surgical management, nutrition support, serum vitamins, and mineral concentrations were collected. The patients were divided into the early-onset PIPO (EO-PIPO; neonatal-onset) and late-onset PIPO (LO-PIPO; infant- or child-onset) groups.

Results: The mean follow-up was 29.5 months (6-153 months). The overall survival rate was 63.8% (37 out of 58 participants) (EO-PIPO, 48.6% [17 out of 35 participants]; LO-PIPO, 87.0% [20 out of 23 participants]). Mortality in the EO-PIPO group was higher than in the LO-PIPO group (P = 0.002). Twenty-one patients died, of which 18 (85.7%) patients had EO-PIPO and 14 (66.7%) patients died under 1 year of age. Infection was the major cause of death. Severe malnutrition was observed at baseline and during follow-up in 25 (43.1%) and 6 (16.2%) patients, respectively. At baseline and during follow-up, the zinc deficiency rates were 29.6% and 26.3%, and those of vitamin D were 26.9% and 52.6%, respectively.

Conclusions: Zinc and vitamin D deficiencies are common in patients with PIPO during follow-up. Therefore, additional supplements should be recommended.

Keywords: intestinal pseudo-obstruction; malnutrition; minerals; nutrition support; parenteral nutrition; pediatrics; vitamins.

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References

REFERENCES

    1. Thapar N, Saliakellis E, Benninga MA, et al. Paediatric intestinal pseudo-obstruction: evidence and consensus-based recommendations from an ESPGHAN-led expert group. J Pediatr Gastroenterol Nutr. 2018;66(6):991-1019.
    1. Faure C, Goulet O, Ategbo S, et al. Chronic intestinal pseudoobstruction syndrome: clinical analysis, outcome, and prognosis in 105 children. French-speaking group of pediatric gastroenterology. Dig Dis Sci. 1999;44(5):953-959.
    1. Goulet O, Jobert-Giraud A, Michel JL, et al. Chronic intestinal pseudo-obstruction syndrome in pediatric patients. Eur J Pediatr Surg. 1999;9(2):83-89.
    1. Ahmed, S, Sharman, T. Intestinal pseudo-obstruction. StatPearls Publishing; 2022.
    1. Emmanuel AV, Kamm MA, Roy AJ, Kerstens R, Vandeplassche L. Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction-a double-blind, placebo-controlled, cross-over, multiple n = 1 study. Aliment Pharmacol Ther. 2012;35(1):48-55.

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