Improved Clinical Outcome of COVID-19 in Hematologic Malignancy Patients Receiving a Fourth Dose of Anti-SARS-CoV-2 Vaccine: An EPICOVIDEHA Report

Jon Salmanton-García^{1

2}, Francesco Marchesi³, Andreas Glenthøj⁴, Yavuz M Bilgin⁵, Jens van Praet⁶, Julio Dávila-Valls⁷, Sonia Martín-Pérez⁷, Jorge Labrador⁸, Jaap van Doesum⁹, Iker Falces-Romero¹⁰, Francesca Farina¹¹, Martin Schönlein¹², Mathilde Chanut¹³, Verena Petzer^{11

14}, Ildefonso Espigado¹⁵, Michelina Dargenio¹⁶, Avinash Aujayeb¹⁷, Uluhan Sili¹⁸, Laura Serrano¹⁹, László Imre Pinczés²⁰, Nick de Jonge²¹, Andrés Soto-Silva²², Caterina Buquicchio²³, Lucia Prezioso²⁴, Monia Marchetti²⁵, Stef Meers²⁶, Alessandro Busca²⁷, Paolo Corradini²⁸, Martin Hoenigl^{29

30}, Philipp Koehler^{1

2}, Laman Rahimli^{1

2}, Gökçe Melis Çolak¹⁸, Elena Arellano³¹, Dominik Wolf^{11

32}, Stefanie Gräfe^{1

2

33}, Emanuele Ammatuna⁹, Caroline Berg Venemyr⁴, Oliver A Cornely^{1

2

34

35}, Livio Pagano^{36

37}

Affiliations

¹ University of Cologne, Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Germany.
² University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Germany.
³ Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
⁴ Department of Hematology, Copenhagen University Hospital-Rigshospitalet, Denmark.
⁵ Department of Internal Medicine, ADRZ, Goes, the Netherlands.
⁶ Department of Nephrology and Infectious diseases, AZ Sint-Jan Brugge-Oostende AV, Belgium.
⁷ Hospital Nuestra Señora de Sonsoles, Ávila, Spain.
⁸ Department of Hematology, Research Unit, Hospital Universitario de Burgos, Spain.
⁹ University Medical Center Groningen, the Netherlands.
¹⁰ La Paz University Hospital, Madrid, Spain.
¹¹ IRCCS Ospedale San Raffaele, Milan, Italy.
¹² Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Germany.
¹³ Centre Hospitalier de Versailles, Le Chesnay, Université Paris-Saclay, UVSQ, Inserm, Équipe "Exposome et Hérédité", CESP, Villejuif, France.
¹⁴ Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck (MUI), Innsbruck, Austria.
¹⁵ Department of Hematology, University Hospital Virgen Macarena-University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS/ CSIC), Universidad de Sevilla (Departamento de Medicina), Spain.
¹⁶ Hematology and Stem Cell Transplant Unit, Vito Fazzi, Lecce, Italy.
¹⁷ Northumbria Healthcare, Newcastle, United Kingdom.
¹⁸ Marmara University, Istanbul, Turkey.
¹⁹ Hospital Universitario de Cabueñes, Gijón, Spain.
²⁰ Division of Hematology, Department of Internal Medicine, University of Debrecen, Hungary.
²¹ Amsterdam UMC, Location VUmc, Amsterdam, the Netherlands.
²² Faculty of Medicine, University of Chile. Infectious Diseases Unity, Salvador Hospital of Santiago, Santiago de Chile, Chile.
²³ Ematologia con Trapianto, Ospedale Dimiccoli Barletta, Italy.
²⁴ Hospital University of Parma - Hematology and Bone Marrow Unit, Parma, Italy.
²⁵ Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
²⁶ AZ KLINA, Brasschaat, Belgium.
²⁷ Stem Cell Transplant Center, AOU Citta' della Salute e della Scienza, Turin, Italy.
²⁸ University of Milan and Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
²⁹ Division of Infectious Diseases and Global Public Health, Department of Medicine, Clinical and Translational Fungal-Working Group, University of California San Diego, CA, USA.
³⁰ Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Austria.
³¹ Department of Hematology, University Hospital Virgen Macarena, Seville, Spain.
³² Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck (MUI), Austria.
³³ Universitätsklinikum Hamburg Eppendorf, Germany.
³⁴ Clinical Trials Centre Cologne (ZKS Köln), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany.
³⁵ German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
³⁶ Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy.
³⁷ Hematology Unit, Università Cattolica del Sacro Cuore, Rome, Italy.

PMID: 36310756
PMCID: PMC9605793
DOI: 10.1097/HS9.0000000000000789

Improved Clinical Outcome of COVID-19 in Hematologic Malignancy Patients Receiving a Fourth Dose of Anti-SARS-CoV-2 Vaccine: An EPICOVIDEHA Report

Jon Salmanton-García et al. Hemasphere. 2022.

. 2022 Oct 25;6(11):e789.

doi: 10.1097/HS9.0000000000000789. eCollection 2022 Nov.

Authors

Affiliations

¹ University of Cologne, Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Germany.
² University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Germany.
³ Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
⁴ Department of Hematology, Copenhagen University Hospital-Rigshospitalet, Denmark.
⁵ Department of Internal Medicine, ADRZ, Goes, the Netherlands.
⁶ Department of Nephrology and Infectious diseases, AZ Sint-Jan Brugge-Oostende AV, Belgium.
⁷ Hospital Nuestra Señora de Sonsoles, Ávila, Spain.
⁸ Department of Hematology, Research Unit, Hospital Universitario de Burgos, Spain.
⁹ University Medical Center Groningen, the Netherlands.
¹⁰ La Paz University Hospital, Madrid, Spain.
¹¹ IRCCS Ospedale San Raffaele, Milan, Italy.
¹² Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Germany.
¹³ Centre Hospitalier de Versailles, Le Chesnay, Université Paris-Saclay, UVSQ, Inserm, Équipe "Exposome et Hérédité", CESP, Villejuif, France.
¹⁴ Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck (MUI), Innsbruck, Austria.
¹⁵ Department of Hematology, University Hospital Virgen Macarena-University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS/ CSIC), Universidad de Sevilla (Departamento de Medicina), Spain.
¹⁶ Hematology and Stem Cell Transplant Unit, Vito Fazzi, Lecce, Italy.
¹⁷ Northumbria Healthcare, Newcastle, United Kingdom.
¹⁸ Marmara University, Istanbul, Turkey.
¹⁹ Hospital Universitario de Cabueñes, Gijón, Spain.
²⁰ Division of Hematology, Department of Internal Medicine, University of Debrecen, Hungary.
²¹ Amsterdam UMC, Location VUmc, Amsterdam, the Netherlands.
²² Faculty of Medicine, University of Chile. Infectious Diseases Unity, Salvador Hospital of Santiago, Santiago de Chile, Chile.
²³ Ematologia con Trapianto, Ospedale Dimiccoli Barletta, Italy.
²⁴ Hospital University of Parma - Hematology and Bone Marrow Unit, Parma, Italy.
²⁵ Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
²⁶ AZ KLINA, Brasschaat, Belgium.
²⁷ Stem Cell Transplant Center, AOU Citta' della Salute e della Scienza, Turin, Italy.
²⁸ University of Milan and Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
²⁹ Division of Infectious Diseases and Global Public Health, Department of Medicine, Clinical and Translational Fungal-Working Group, University of California San Diego, CA, USA.
³⁰ Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Austria.
³¹ Department of Hematology, University Hospital Virgen Macarena, Seville, Spain.
³² Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck (MUI), Austria.
³³ Universitätsklinikum Hamburg Eppendorf, Germany.
³⁴ Clinical Trials Centre Cologne (ZKS Köln), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany.
³⁵ German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
³⁶ Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy.
³⁷ Hematology Unit, Università Cattolica del Sacro Cuore, Rome, Italy.

PMID: 36310756
PMCID: PMC9605793
DOI: 10.1097/HS9.0000000000000789

No abstract available

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References

1. Pagano L, Salmanton-García J, Marchesi F, et al. COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA). J Hematol Oncol. 2021;14:168. - PMC - PubMed
1. Cesaro S, Ljungman P, Mikulska M, et al. Recommendations for the management of COVID-19 in patients with haematological malignancies or haematopoietic cell transplantation, from the 2021 European Conference of Infections in Leukaemia (ECIL-9). Leukemia. 2022;36: 1467–1480. - PMC - PubMed
1. Pagano L, Salmanton-García J, Marchesi F, et al. COVID-19 in vaccinated adult patients with hematological malignancies: preliminary results from EPICOVIDEHA. Blood. 2022;139:1588–1592. - PMC - PubMed
1. Christensen PA, Olsen RJ, Long SW, et al. Signals of significantly increased vaccine breakthrough, decreased hospitalization rates, and less severe disease in patients with coronavirus disease 2019 caused by the Omicron variant of severe acute respiratory syndrome coronavirus 2 in Houston, Texas. Am J Pathol 2022; 192: 642–652. - PMC - PubMed
1. Bar-On YM, Goldberg Y, Mandel M, et al. Protection by a fourth dose of BNT162b2 against Omicron in Israel. N Engl J Med. 2022;386:1712–1720. - PMC - PubMed

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Improved Clinical Outcome of COVID-19 in Hematologic Malignancy Patients Receiving a Fourth Dose of Anti-SARS-CoV-2 Vaccine: An EPICOVIDEHA Report

Affiliations

Improved Clinical Outcome of COVID-19 in Hematologic Malignancy Patients Receiving a Fourth Dose of Anti-SARS-CoV-2 Vaccine: An EPICOVIDEHA Report

Authors

Affiliations

References

LinkOut - more resources

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